| Objective By observing the changes of infection-related indicators and prognosis,we compared the anti-infective effects of cefuroxime sodium for 2 days and 7 days after non-stop coronary artery bypass grafting,so as to guide rational drug use in the clinic.METHODS A total of 102 male and female patients undergoing non-stop coronary artery bypass grafting from January 2018 to December 2019 were selected for retrospective analysis.According to the actual duration of antibiotic prevention,the patients were divided into a control group and an experimental group.The experimental group continued to use cefuroxime sodium for 2 days after operation,and the control group continued to use cefuroxime sodium for 7 days after operation.Cefuroxime sodium 1.5g was injected intravenously,and cefuroxime sodium 1.5g/q8h was intravenously infused immediately after returning to the intensive care unit.A retrospective study of the experimental data was carried out by consulting medical orders,medical records,blood routine,C-reactive protein,procalcitonin and other data in the medical records.By comparing the changes of infection-related indicators and prognosis of the two groups,the effect of cefuroxime sodium2 days and 7 days anti-infection on perioperative prevention of non-stop coronary artery bypass grafting was compared.The X~2 test was used to compare the infection indexes and infection-related factors between the two groups.Logistic regression analysis of risk factors was performed on infected patients to compare the differences in infection risk factors.RESULTS According to the inclusion and exclusion criteria,a total of 102 patients were collected,including 53 in the control group and 49 in the experimental group.The control group included 36 males and 17 females,aged(60.26±6.36)years;the experimental group had 32 males and 17 females,aged(62.02±7.07)years.There was no statistically significant difference in age(P=0.189),gender(P=0.779),smoking(P=0.606),hypertension(P=0.930),and diabetes(P=0.336)between the two groups.There were 7 cases(13.2%)of respiratory infections in the control group,6 cases(12.2%)of respiratory infections in the experimental group,and 1 case(2.0%)of incision infections(7 cases(14.3%)).There was no significant difference in postoperative infection rates between the two groups(P=0.874);the number of infected patients was 14 and the number of non-infected patients was 88.The risk factors of infected patients were compared,smoking(P=0.006),diabetes(P=0.040),the 7th day after surgery There were statistically significant differences in body temperature(P<0.001),operation time(P=0.026),three times after operation(P<0.001),(P=0.005),(P=0.003),three times after operation Procalcitonin(P<0.001),(P<0.001),(P=0.005)were statistically different.There was no statistical difference in C-reactive protein(P=0.624)on the first day after surgery,on days 3 and 7 C-reactive protein(P<0.001)and(P<0.001)were statistically different;Logistic regression analysis of infected patients(Wald=5.972,P=0.015),operation time(Wald=4.008,P=0.045)were infected Independent risk factors.CONCLUSION 1.Preventive use of cefuroxime sodium in patients after non-stop bypass bypass can effectively prevent postoperative infection and reduce the incidence of infection.2.Antibiotic prophylaxis 48 hours after non-stop skipping is effective.Prolonging the use of antibiotics will not bring benefits and will increase the risk of drug resistance and infection in patients.There are no special circumstances and no need to extend the time of preventive medication.3.Smoking and the length of operation are risk factors for infection after bypass surgery.Patients with the above factors have a higher probability of infection after surgery.Patients with increased postoperative inflammation-related indicators have a higher risk of infection.Such patients need to be strengthened to prevent infection and control it at an early stage to avoid delays that could lead to aggravation of the disease. |
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