| Objectives This study aims to investigate the relationship of soluble lectin like oxidized low density lipoprotein receptor 1(sLOX-1)and endothelial cell-specific molecule 1(ESM-1)with acute cerebral infarction and its carotid atherosclerosis.Methods A total of 251 patients with acute cerebral infarction admitted to the Department of Neurology of North China University of Science and Technology Affiliated Hospital between October 2018 and December 2019 were enrolled in this study and divided into non-atherosclerosis group and atherosclerosis group in accordance with the intima-media thickness(IMT);According to the stability of carotid plaques,they were divided into a stable plaque group and an unstable plaque group;Based on the degree of carotid stenosis,they were classified into non-stenosis group,and mild,moderate and severe stenosis groups;In line with Crouse scores of carotid plaques,they were divided into mild,moderate and severe atherosclerosis groups.Fifty participates who came to the North China University of Science and Technology Affiliated Hospital for physical examination were selected as controls in the corresponding period.The general data of patients and the results of related laboratory tests were collected.ELISA was used to determine the level of serum sLOX-1 and ESM-1.The statistical analysis was carried out for sLOX-1,ESM-1 and clinical data.Results 1 The levels of TC,TG,LDL-C and Hcy in the case group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of sLOX-1 and ESM-1 in the case group were significantly higher than those in the control group(P<0.05).The association analysis of sLOX-1 and ESM-1 with acute cerebral infarction was conducted with sLOX-1 and ESM-1?population mean as exposure,and the results showed that serum sLOX-1 and ESM-1 were correlated with acute cerebral infarction(P<0.05).Multivariate Logistic regression analysis showed that sLOX-1 and ESM-1 were still risk factors for acute cerebral infarction after controlling for other risk factors(OR=3.931,P<0.05;OR=2.755,P<0.05;OR=4.560,P<0.05;OR=3.432,P<0.05).2 The serum levels of sLOX-1 and ESM-1 in the recurrent cerebral infarction group were significantly higher than those in the first cerebral infarction group(P<0.05).The correlation analysis of sLOX-1 and ESM-1 with acute cerebral infarction recurrence showed that serum sLOX-1 and ESM-1 were correlated with acute cerebral infarction recurrence(P<0.05).Multivariate Logistic regression analysis showed that hypertension and sLOX-1 were the risk factors for the recurrence of acute cerebral infarction(OR=0.755,P<0.05;OR=1.966,P<0.05).3 In the general data and laboratory examination results,the differences of smoking,hypertension and TC in the acute cerebral infarction patients with atherosclerosis group and those without atherosclerosis group were statistically significant(P<0.05).The serum levels of sLOX-1 and ESM-1 in patients with atherosclerosis were significantly higher than those in patients without atherosclerosis(P<0.05).Correlation analysis showed that serum sLOX-1 and ESM-1 were associated with carotid atherosclerosis in patients with acute cerebral infarction(P<0.05).Multivariate Logistic regression analysis showed that smoking,hypertension,sLOX-1 and ESM-1 were risk factors for carotid atherosclerosis in acute cerebral infarction after controlling for other risk factors(OR=2.923,P<0.05;OR=2.526,P<0.05;OR=2.879,P<0.05;OR=3.283,P<0.05).4 The levels of TG and Hcy in the unstable plaque group of patients with acute cerebral infarction were higher than those in the stable plaque group,and the difference was statistically significant(P<0.05).The levels of sLOX-1 and ESM-1 in the patients with unstable plaque were significantly higher than those in the stable plaque group,and the differences were statistically significant(P<0.05).Correlation analysis results suggested that serum sLOX-1 and ESM-1 were correlated with the stability of carotid artery plaque in acute cerebral infarction(P<0.05).Multivariate Logistic regression analysis showed that TG,sLOX-1 and ESM-1 were the risk factors for the stability of carotid plaque in acute cerebral infarction(OR=2.530,P<0.05;OR=2.760,P<0.05;OR=3.507,P<0.05).5 The differences of smoking and TC between the mild,moderate and severe stenosis group and the non-stenosis group were statistically significant(P<0.05).The levels of sLOX-1 and ESM-1 in the patients with mild,moderate and severe stenosis group were significantly higher than those without stenosis group(P<0.05).Pearson correlation analysis was conducted to analyze the correlation between the serum sLOX-1 and ESM-1 levels in patients with acute cerebral infarction and the degree of carotid artery stenosis.The results showed that the serum sLOX-1 and ESM-1 in patients with acute cerebral infarction were positively correlated with the degree of carotid artery stenosis(P<0.05).Ordered Logistic regression analysis found that sLOX-1 and ESM-1 were risk factors for carotid artery stenosis in patients with acute cerebral infarction(OR=2.321,P<0.05;OR=2.255,P<0.05).6 There was no significant difference in sLOX-1 and ESM-1 between acute cerebral infarction patients with mild,moderate and severe atherosclerosis(P>0.05).Conclusions 1 Serum sLOX-1 and ESM-1 are associated with the onset and recurrence of acute cerebral infarction.They are risk factors for attacks and relapses of acute cerebral infarction.2 Serum sLOX-1 and ESM-1 levels are related to the carotid atherosclerosis,carotid plaque stability and degree of stenosis in patients with acute cerebral infarction but not correlated with carotid plaque scores.Serum sLOX-1 and ESM-1 levels are risk factors for carotid atherosclerosis,carotid plaque stability and degree of stenosis in patients with acute cerebral infarction.Figure 0;Table 31;Reference 144... |
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