Observation On The Curative Effect Of Traditional Chinese Medicine External Bath Combined With Mecobalamine In The Treatment Of Oxaliplatin-induced Peripheral Neuropathy

Objective:Through the observation of the effect of traditional Chinese medicine external bath combined with mecobalamine and single mecobalamine on the treatment of oxaliplatin-induced peripheral neuropathy,the clinical treatment value of traditional Chinese medicine external bath on oxaliplatin-induced peripheral neuropathy was comprehensively analyzed.Methods:Through collecting the data,a total of 60 patients with colorectal malignancies who received treatment in the inpatient department of oncology department of sichuan hospital of traditional Chinese medicine from January 2019 to December 2019 and met the inclusion criteria were counted.The 60 tumor patients were randomly divided into control group and experimental group,with 30 patients in each group.In the control group,patients were treated with mecobalamin tablets(0.5mg Po tid)and warm water external bath.In the experimental group,patients were treated with mecobalamin tablets(0.5mg Po tid)and traditional Chinese medicine external bath treatment.The duration of treatment in the two groups of this study was5 days.Subject after the experiment to collect statistics and two groups of patients with comprehensive score of symptoms,life quality and adverse reactions and other related experimental data and statistical information and statistical analysis,and the combined use of Chinese medicine external bath for treating peripheral neuropathy associated with oxaliplatin into clinical curative effect and safety evaluation.Results:In the observation and analysis of the clinical efficacy of traditional Chinese medicine external bath combined with methylcobalamin in the treatment of oxaliplatin-induced peripheral neuropathy,there was no statistically significant in gender,age,tumor type,stage,OIPN grade,KPS score and quality of life,OXA cumulants,TCM syndrome integral between the experimental group and the control group before admission(P>0.05),comparable.In terms of the efficacy of OIPN,the OIPN grade decreased in both groups after 48h of treatment,butχ~2=1.833,P>0.05 in the experimental group,andχ~2=0.394,P>0.05 in the control group,which was not statistically significant.After 5d of treatment,the OIPN grade was significantly decreased in the experimental groupχ~2=24.760,P<0.001,and in the control groupχ~2=8.080,P<0.05,which was statistically significant.And the experimental group than the control group decreased significantly,χ~2=9.487,P<0.05.As for the TCM syndrome score,it was obtained through statistical processing and analysis of experimental data between the two groups.After 48h of continuous treatment,the TCM syndrome score of both groups decreased,but the score of patients in the experimental group 93.33%and the control group 96.67%did not decrease by 30%,so it was judged to be invalid.between the two groups(χ~2=0.351,P>0.05).After 5days of continuous treatment,the total effective rate of the experimental group was90%,compared with 48h,χ~2=42.228,P<0.001,with statistical significance.The effective rate of the control group was 70%,compared with 48h,χ~2=28.834,P<0.001,with statistical significance,however,by analyzing the data of the two groups before and after treatment,it can be concluded that the decrease of the experimental group is more obvious than that of the control group,and the results are statistically significant,χ~2=8.396,P<0.05.And Karnofsky performance status score of two groups of patients before and after treatment,after collection,the experimental data and statistical analysis,after 48 h of continuous treatment,both the experimental group and control group,two groups of patients before KPS score relative treatment have varying degrees of increase but not obvious,and there is no statistically significance both sets of data,the P values were greater than 0.05;After 5 days of continuous treatment,the KPS score was improved compared with that before treatment,and the difference was statistically significant,with T=-7.940,P<0.001 in the experimental group and T=-4.039,P<0.001 in the control group.However,the improvement in the experimental group was more significant than that in the control group,with T=3.260,P<0.05,which indicates a statistically significant difference.After treatment,the quality of life in both groups overall score compared to those before treatment,and the scores of the six functional areas of the two groups were significantly improved.After statistical treatment,it was concluded that there was a statistical difference between the two groups(P<0.05).In addition,the score of the experimental group was more significantly improved than that of the control group,and the difference was statistically significant(P<0.05).During the study period,there were no obvious abnormal changes in the general vital signs,blood routine,liver and kidney function caused by the drugs used in the study.In addition,there were almost no adverse reactions such as skin irritation(mainly skin flushing,itching and rash)during the experiment,and the difference was not statistically significant(P>0.05).Conclusion:Traditional Chinese medicine external bath combined with mecobalamine can effectively alleviate oxaliplatin related peripheral neuropathy,and it can effectively improve the quality of life of patients,the results of this experiment reflect the consistency of the TCM pathogenesis analysis of OIPN cold coagulation and blood stasis in this experiment,which is of certain reference for the clinical diagnosis and treatment of OIPN,and its safety is high,no obvious adverse side effects,worthy of clinical application.