The Clinical Significance Of FGFR2 And FGFR4 Expression In Bladder Urothelial Carcinoma

Objective:To detect the expression and clinical significance of fibroblast growth factor receptor 2(FGFR2)and fibroblast growth factor receptor 4(FGFR4)in bladder urothelial carcinoma(BUC)tissues and normal urothelial tissues.Methods:We detected the expression of FGFR2 and FGFR4 in 67 BUC tissue and 20 normal bladder tissue by immunohistochemistry.The correlations between FGFR2、FGFR4 expression rates and prognosis were evaluated according to clinical features.Spearman correlation analysis was used for their correlation.Results:1.The expression rate of FGFR2 in BUC was statistically lower than that in normal bladder tissues(P<0.05).The rate of FGFR2 expression in BUC in the high-grade group,muscle-invasion group,and postoperative-relapse group were significantly lower than those in the corresponding group(P<0.05).The survival analysis showed that the postoperative survival rate of BUC patients with FGFR2-positive group was significantly higher than that FGFR2-negative group(P<0.05),but the FGFR2 expression rate was not an independent risk factor for the prognosis of patients with BUC.2.The expression rate of FGFR4 in BUC was not statistically different from that in normal bladder tissue(P>0.05).The expression level of FGFR4 was not statistically significant with the clinical characteristics(P > 0.05).The survival analysis showed that FGFR4 expression rate and survival rate were not statistically significant(P > 0.05).3.Spearman correlation analysis of FGFR2 and FGFR4 expression in BUC: there were no correlation(P>0.05).Conclusions:1.FGFR2 may be involved in the occurrence and progression of BUC and plays a role in tumor inhibition.It may affecte the prognosis of patients with BUC,but it could not be used as an independent predictor.2.FGFR4 is not significantly affect the occurrence and progression of BUC and is not related to the prognosis of BUC patients.3.There is no correlation between FGFR2 and FGFR4 expression in BUC.