Lipid Levels And The Risk Of New-onset Atrial Fibrillation: A Systematic Review And Dose-response Meta-analysis

Background and purpose:Lipid Levels is closely related to our health,but whether Lipid Levels is associated with AF remains controversial.We used a meta-analysis to examine the overall association between Lipid Levels and New-Onset atrial fibrillation(AF).Methods:PubMed and EMBASE databases were searched up to December 20th 2019.We conducted a systematic review and meta-analysis of prospective studies to clarify the association between lipid l evels and the risk of New-Onset AF.We made a quantitative analysis of the association between Lipid Levels and the risk of New-Onset AF.Results:16 cohort studies containing 4,032,638 participants were included in this meta-analysis,and 42,825 AF patients were observed.Summary relative risks(RRs)and 95%confidence intervals(CIs)were calculated using random effects models and fixed effects models.The summary RR was 0.95(95%CI 0.93–0.96,I~2=74.6%,n=13)per 1mmol/L increment in total cholesterol,and 0.95(95%CI 0.92–0.97,I~2=71.5%,n=10)per 1 mmol/L increase in Low-density lipoprotein cholesterol(LDL-C),and 0.97(95%CI 0.96–0.99,I~2=26.1%,n=11)per 1mmol/L increase in High-density lipoprotein cholesterol(HDL-C),and1.00(95%CI 0.96–1.03,I~2=81.1%,n=8)per 1 mmol/L increase in triglyceride.Conclusion:Higher levels of TC,LDL-C and HDL-C were inversely associated with risk of New-Onset AF.Triglyceride has no effect on New-Onset AF.