Effective Observation Of Different Treatment Regimens On Functional Dyspepsia Patients With Helicobacter Pylori Infection And Mila To Moderate Anxiety And Depression

ObjectiveTo observe the effects of different treatment regimens on clinical symptoms and quality of life in patients with functional dyspepsia(FD)combined with Helicobacter pylori(Hp)infection and mild to moderate anxiety and depression.MethodsFrom Jun.2018 to Jun.2019,90 FD patients with Hp infection and mild to moderate anxiety and depression were randomly divided into three groups: A,B,and C.Group A was treated with quadruple Hp eradication treatment for 2 weeks,and then continued to be treated with antacid drug for 4 weeks.Group B was treated with flupentixol and melitracen tablets for 6 weeks.Group C was treated with quadruple Hp eradication treatment for 2 weeks and at the same time treated with flupentixol and melitracen tablets for 6 weeks.The dyspepsia symptom score,anxiety score,depression score and quality of life score were evaluated before and after 6weeks of treatment.Results1.Compared with before treatment,the average scores of dyspepsia symptom was reduced in group A,B and C(P<0.05),and the total effective rate on dyspepsia symptoms was 16.67%(5/30),82.00%(23/28)and83.33%(25/30).After 6 weeks of treatment,there was no significant change of anxiety,depression and quality of life scores in group A(P>0.05).The scores of anxiety and depression in group B and C were significantly lower,and the quality of life score was significantly higher(P<0.05).2.Compared with group A,there were significant differences of all the scores in group B and group C after 6 weeks of treatment(P<0.05),but there was no significant difference between group B and group C(P>0.05).3.During the treatment period,the incidence of adverse drug reactions in each group was 10.00%,10.71% and 16.67%,respectively,with mild symptoms and no statistical significance.ConclusionFor patients with FD,combined with Hp infection and mild to moderate anxiety and depression,routine Hp eradication therapy might be with limited improvement in symptoms,while anti-anxiety or depression treatment could effectively improve the clinical symptoms,which benefited no less than Hp eradication combined.