Clinical Observation Of Shugan Jianpi Decoction In The Treatment Of Functional Dyspepsia Upper Abdominal Pain Syndrome (Syndrome Of Liver Depression And Spleen Deficiency)

Purpose1.By analyzing the case data of patients with functional dyspepsia epigastric pain syndrome,the relationship between different factors and functional dyspepsia epigastric pain syndrome was studied,and the influencing factors of its quality of life were discussed,so as to understand the survival status of patients from the perspective of quality of life.2.To observe the clinical efficacy of Shugan Jianpi Decoction in the treatment of functional dyspepsia upper abdominal pain syndrome(Syndrome of liver stagnation and spleen deficiency),and to explore the therapeutic advantage of Shugan Jianpi decoction through comparative analysis with western medicine,so as to provide theoretical basis and clinical thinking for TCM treatment of functional dyspepsia upper abdominal pain syndrome(syndrome of liver stagnation and spleen deficiency).Method1.A questionnaire survey was conducted in 200 patients with functional dyspepsia epigalgia syndrome.The general situation,Hp infection,TCM four-diagnosis information,anxiety and depression status and quality of life of the patients were recorded,and the influencing factors of quality of life were explored.Excel was used to establish a database for the collected data,and SPSS 25.0 software was used for statistical analysis.2.According to random number table method in 60 patients with functional dyspepsia abdominal pain syndrome(liver depression,spleen deficiency)patients into two groups,the treatment group,30 cases with liver spleen decoction,the control group,30 cases with rabeprazole azole sodium enteric-coated metformin hydrochloride 20 mg,once daily,joint fluorine pp thiamethoxam tons of beauty Qu Xin 0.5 mg: 10 mg,1 times a day,regular treatment of 4 weeks.TCM syndrome score,FDDQL,HAMA,HAMD,safety evaluation and recurrence rate were observed before and after treatment.All data were analyzed by SPSS25.0 software,and P<0.05 was statistically significant.ResultThe results of epidemiological investigation showed that there were 200 EPS patients,including 84 males and 116 females,with a male/female ratio of 1:1.4.The oldest person is 70 years old,and the youngest is 19 years old,among which the 61-70 age group accounts for the largest proportion(26%).Most patients with disease course of six months to one year;67cases had past history.In the occupation distribution,the brain workers accounted for the largest proportion;Poor mood and diet are the main causes of the disease;There are partial diet,the most patients with spicy food;41 patients were infected with Hp.The top four TCM symptoms are: epigastric pain,epigastric distention,acid reflux,irritability;The tongue is mainly red,the moss is thin and white,and the pulse is smooth.The distribution characteristics of TCM syndromes were as follows: liver depression and spleen deficiency syndrome(38.5%)> disharmony between liver and stomach syndrome(20%)>deficiency and cold syndrome of spleen and stomach(13%)>combination of cold and heat syndrome(11.5%)>diet injury to stomach syndrome(9%)>dampness-heat syndrome of spleen and stomach(8%);The mean scores of anxiety and depression were higher than normal.In terms of quality of life,compared with healthy people,EPS patients showed a decrease in all dimensions and fields,with statistical significance(P<0.05).In terms of gender,male patients had higher levels of physiological function PF,social function SF and mental health MH than female patients,with statistically significant differences(P<0.05).In terms of age,there were significant differences in physiological function RP,physical pain BP,general health GH,energy VT,emotional function RE and mental health MH among different age groups(P<0.05).In terms of occupation,there were significant differences in physical pain BP,general health GH,energy VT,emotional function RE and mental health MH among different occupations(P<0.05).In terms of course of disease,there were significant differences in physical pain BP,energy VT,general health GH,emotional function RE and mental health MH(P<0.05).In terms of anxiety and depression,there were significant differences in physiological function RP,energy VT and mental health MH among different anxiety states(P<0.05),and significant differences in physiological function RP and energy VT among different depression states(P<0.05).Hp infection and TCM syndrome type had no statistical significance in all dimensions of life quality(P>0.05).2.Before treatment,there were no significant differences in age,gender,TCM syndrome,FDDQL,HAMA and HAMD scores between 2 groups(P>0.05).Comparison of TCM syndrome: after treatment,the scores of the treatment group were improved compared with those before treatment(P<0.05),while the scores of epigastric pain,epigastric fullness,belching,acid reflux,and irritability in the control group were improved compared with those before treatment(P<0.05).After treatment,the scores of epigastric pain,epigastric fullness,noisy,belching,acid reflux,greasy mouth and loose stools in the treatment group were better than those in the control group(P<0.05).FDDQL comparison: after treatment,the scores in all fields were improved in the treatment group compared with before treatment and the control group compared with before treatment(P<0.05).After treatment,the treatment group was better than the control group in improving daily life,discomfort,health feeling and pressure(P<0.05).HAMA and HAMD: After treatment,the scores in HAMA and HAMD in the treatment group were significantly lower than those before treatment(P<0.05),and those in the control group were significantly lower than those before treatment(P<0.05).After treatment,there was no statistical difference in HAMA and HAMD scores between the treatment group and the control group(P>0.05).Drug safety: There were no adverse reactions in 2 groups before and after treatment.Comparison of recurrence rate: the recurrence rate of the control group(28.57%)was higher than that of the treatment group(7.14%),and there was a significant difference in the recurrence rate between the two groups(P<0.05).In conclusion1.The quality of life of EPS patients was significantly lower than that of healthy people.Gender,age,occupation,course of disease,anxiety and depression were correlated with the quality of life of patients in different dimensions.To further understand the quality of life of EPS patients,we should focus on women,patients over 40 years old,retirees,patients with a long course of disease,and patients with anxiety and depression.2.Both treatment group and control group could improve TCM syndromes,anxiety and depression state,and improve the quality of life.Compared with rapeprazole sodium enteric coated tablet combined with flupentixol melitoxin tablet,Shugan Jianspleen Decoction has obvious advantages in treating epigastric pain,epigastric fullness,noise,belching,acid reflux,greasy mouth,stool,FDDQL daily life,discomfort,health feeling,pressure and other aspects of TCM syndrome.According to the improvement of HAMA and HAMD,the efficacy of the two groups was similar.This study confirmed that the method of soothing the liver and strengthening the spleen can effectively relieve the clinical symptoms of patients,improve anxiety and depression,improve the quality of life,and has a high safety.