Correlation Between MAO,AST And GRACE Scores In Patients With Non-st-segment Elevation Acute Coronary Syndrome

Objective:To investigate the relationship between plasma monoamine oxidase(monoamine oxidase,MAO)and aspartate transaminase(aspartate transaminase,AST)and global acute coronary events registry(global acute coronary events registry,GRACE)risk score in patients with non-st-segment elevation acute coronary syndrome(non-st-segment elevation acute coronary syndrome,NSTE-ACS).Methods:80 patients with NSTE-ACS and 50 healthy controls with negative results of coronary angiography with chest pain were selected.According to GRACE score,patients with NSTE-ACS were divided into three groups: low risk group(GRACE score ≤ 108),medium risk group(GRACE score 109 ~ 140)and high risk group(GRACE score > 140).Creatine kinase isoenzyme,troponin I,N-terminal pro-brain natriuretic peptide,creatinine,low density lipoprotein,high density lipoprotein,aspartate transaminase and monoamine oxidase were measured in patients with NSTE-ACS and healthy controls.The differences of each index between NSTE-ACS patients and healthy controls,the differences of the above indexes in high,middle and low risk groups were compared,and the correlation between them and GRACE score was analyzed.Results:1.Comparing the clinical data of control group,unstable angina(unstable angina,UA)group and non-ST segment elevation myocardial infarction(non-ST segment elevation myocardial infarction,NSTEMI)group,the age of UA group and NSTEMI group was higher than that of control group,the values of AST and N-terminal pro brain natriuretic peptide(N-terminal pro brain natriuretic peptide,NT-proBNP)of NSTEMI group were significantly higher than those of control group and UA group,and the high density lipoprotein(high density lipoprotein,HDL)value of UA group was lower than that of control group.The MAO value of UA group and NSTEMI group was higher than that of control group,and that of NSTEMI group was higher than that of UA group,the difference was statistically significant.2.According to the results of chi-square test,there were significant differences in the distribution of hypertension,diabetes and smoking in control group,UA group and NSTEMI group.3.The age of middle risk group and high risk group was higher than that of low risk group,and the AST value,NT-proBNP value of high risk group were significantly higher than those of low risk group and middle risk group.The creatinine and the number of lesions in the highrisk group was higher than that in the low-risk group.The MAO value of high risk group and middle risk group was higher than that of low risk group,and the MAO value of high risk group was the highest.The difference was statistically significant.4.There was no difference in the distribution of sex,hypertension history,diabetes history and smoking history in the risk degree of GRACE.5.There was a positive correlation between MAO and GRACE score,the linear fitting degree was R2 = 0.775,and the Pearson correlation coefficient was 0.880(P < 0.001).6.AST and GRACE scores were positively correlated,linear fitting R2=0.335,and Pearson correlation coefficient was 0.579.7.Multiple linear regression analysis showed that MAO,age and creatinine(creatinine,Cr)value had positive correlation on the score of GRACE.From the standardized regression coefficient,it could be seen that the value of Mao had a greater influence on the score of GRACE.Conclusion: the level of monoamine oxidase in patients with NSTE-ACS is closely related to GRACE score.Conclusions:1.MAO and AST were significantly higher in patients with nste-acs than in the control group,so MAO and AST may play an important role in the onset and progression of coronary heart disease.2.There was a good positive correlation between MAO AST and GRACE integral in patients with nste-acs,which reflected the consistency between MAO AST level and GRACE integral.3.Multivariate logistic regression analysis showed that MAO is an independent risk factor for coronary heart disease,so MAO may be used as a supplement to the risk assessment of nste-acs in the future,which can assist clinicians to conduct more rapid and accurate early assessment of wind in patients.