Corrlation Between Plasma NLRP3 And Its Downstream Factors And Grace Score In Patients With Non ST Segment Elenation Acute Coronary Syndrome

Objective To analyze the levels of NLRP3 and its relevant factors inteleukin-1(IL-1 beta),inteleukin-1(IL-18)in patients with NSTE-ACS(non-ST seggment elevation acute coronary syndrome)and its connections with GRACE(Global Registry of Acute Coronary Events)risk scores.To investigate their signification in the dangerous classification and the prognostic value of the MACE's incidence rate during the hospital stay of the patients in NSTE-ACS.Method from march 2015 to march 2016,141 patients who hospitalized in cardiovascular ward I,Liuzhou Worker's Hospital were included.All patients were preformed coronary angiography.The proportion contrast figure about capacity occupied in different series.The number of NSTE-ACS is 90 and the UA is 24,others 27 all belongs to the contrast group.As everyone knows,all the patients of ACS can be divided into 3 type:UA,NSTE-ACS and AP.Now in our study,the contrast group can be added.Meanwhile,we can divide our targets into four groups:highest-risk group(?140),mid-risk group(among 109 to 139),low-risk group(?108)and the contrast group on the basis of GRACE.Before this,we should record all the patients include age,sex,heart rate,blood pressure,smoking history,hypertension and diabetes as much detail as possible.Firstly,we must analyse the difference of basis data,NLRP3,IL-1beta,IL-18 among all the groups.And then,analyse the relativity of NLRP3,IL-1?,IL-18.Lastly,through the receiver Operating Characteristic Curve(ROC curve)figure out the area and the optimal truncation point.Analysing their signification in the dangerous classification and the prognostic value of the MACE 's incidence rate during the hospital stay of the patients in NSTE-ACS.All this can we employ the method which be known as ELISA(Enzyme Linkde Immunosorbent Assay).Result(1)there was no significant difference between the treatment groups by comparing with the patient's basic data such as age,gender,hypertension prevalence rate,diabetes prevalence rate,heart rate,blood lipid,serum creatinine level.(2)The plasma levels of NLRP3,IL-1beta were significantly higher than the control group(P<0.05)by comparing with NSTEMI group,UA group and AP group.The plasma levels of NLRP3,IL-1beta were significantly higher than UA group and AP group(P<0.05)by comparing with NSTEMI group.when it comes to the L-18 levels,there was not significant difference between each group.(3)The plasma levels of NLRP3,IL-lbeta,hsCRP and white blood cell were significantly higher than the contrast group by comparing with highest-risk group,mid-risk group and low-risk group.The plasma levels of NLRP3,IL-1?,hsCRP and white blood cell were significantly higher than low-risk group by comparing with highest-risk group and mid-risk group.And when comparing with mid-risk group,highest-risk group gets one step ahead of it.The plasma levels of IL-18 were significantly higher than the contrast group by comparing with highest-risk group,mid-risk group and low-risk group.But there was not significant difference between mid-risk group,low-risk group and the contrast group.For highest-risk group,The plasma levels of NLRP3,IL-1beta and IL-18 were significantly higher than other group,it can make a signal that we could easily identify patients who at this rank.(4)There was an active correlation among the levels of NLRP3,IL-land IL-18 with GRACE score.(5)Through the ROC curve,we can figure out the areas are 0.921,0.762 and 0.692,correspond to NLRP3,IL-1 beta and IL-18 and the optimal truncation points are 133.77pg/ml,7.83pg/ml and 15.07pg/ml.Conclusion By Comparing with the IL-1 beta and IL-18,the level of plasma NLRP3 and the score on GRACE are positive correlated with the signification in the dangerous classification and the prognostic value of the MACE 's incidence rate during the hospital stay of the patients in NSTE-ACS.The plasma level of NLRP3 may be a significant serum marker of prognosis judgement for the patients in NSTE-ACS.