Changes In Serum Adiponectin Levels In Patients With Nonalcoholic Fatty Liver Disease And Analysis Of Related Factors

Objective:By testing in patients with nonalcoholic fatty liver disease(NAFLD)and nonalcoholic fatty liver disease combined with type 2 diabetes(NAFLD combined T2 DM group),type 2 diabetes(T2DM)and normal control group(NG)in patients with serum adiponectin(ADPN)levels in serum,analysis and discussion on ADPN level changes in serum in patients with NAFLD,study its relationship with the related clinical indicators at the same time,trying to adiponectin as fatty liver disease screening and its severity evaluation is an important serological biomarker,At the same time,it provides the clinical research foundation for the treatment of fatty liver.Methods:A total of 120 outpatient or inpatient patients in our hospital from September 2018 to December 2019 were selected and divided into four groups: 30 NAFLD patients(18 males/12 females),30 NAFLD patients with T2DM(13 males/17 females),30 T2 DM patients(19 males/11 females),and 30 normal control patients(13 males/17 females).General information of all subjects was recorded in detail,such as height,weight,waist circumference,hip circumference,and body mass index(BMI)and waist-hip ratio(WHR)were calculated.Each patient underwent a Fibroscan,in which the CAP value represented the degree of hepatic steatosis(dB/m)and the LSM value(kPa)represented the liver elasticity,and the detection data of each participant were recorded.(3)related laboratory index determination: by using enzyme-linked immunosorbent(ELISA)to detect groups of adiponectin levels,draw the fasting blood in our hospital since morning biochemistry checkout room determine fasting plasma glucose(FPG),fasting insulin(INS),low density lipoprotein(LDL),high-density lipoprotein(HDL),total cholesterol(TC),triglyceride(TG),glutamic acid transaminase(ALT),aspartate aminotransferase(AST),r-GGTP(gamma glutamyl transpeptidase)(r-GGT),and other indicators.Homeostasis mode assessment was used to calculate the insulin resistance index(HOMA-IR).Results:(1)FPG,FINS,HOMA-IR,LSM,CAP,TG,TC,LDL,ALT,AST,GGT in NAFLD group were higher than N group,and HDL was lower than N group(P<0.05);FPG,FINS,HOMA-IR,LSM,CAP,TG,TC,LDL,ALT,AST,GGT were higher in NAFLD+T2DM group than in N group,and HDL was lower than N group(P<0.05);FPG,FINS,HOMAIR,LSM,TG,TC,LDL,ALT,AST,GGT were higher in NAFLD+T2DM group than in NAFLD group,and HDL was lower than in NAFLD group(P<0.05);FPG,FINS,HOMAIR,LSM,CAP,TG,TC,LDL,ALT,AST and GGT levels in NAFLD+T2DM group were higher than those in T2 DM group(P<0.05);(2)The ADPN level of NAFLD group and NAFLD group +T2DM group was lower than that of N group(P<0.05),and the ADPN level of NAFLD+T2DM group was significantly lower than that of NAFLD group(P<0.05);(3)Serum ADPN level was negatively correlated with FPG,FINS,homa-ir,LSM,CAP,TG,TC,LDL,ALT,AST,GGT,and was positively correlated with HDL;(4)ADPN level in NAFLD group and NAFLD+T2DM group was negatively correlated with CAP value and LSM value in the two groups;FPG,FINS,homa-ir,LSM value,CAP value,TG,TC,LDL,ALT,AST,GGT and other indicators are not independent factors affecting ADPN.Conclusion:(1)Serum ADPN level of NAFLD patients was significantly lower than that of normal people,and was positively correlated with the severity of fatty liver,which could help diagnose and evaluate the severity of fatty liver;(2)Adiponectin levels in patients with NAFLD with T2 DM were further decreased compared with those with NAFLD alone or T2 DM alone.Adiponectin may be an independent risk factor for the onset of fatty liver;The level of serum ADPN is inversely proportional to the severity of glucose and lipid metabolism disorders,insulin resistance and liver damage,and is closely related to the pathogenesis of NAFLD and T2 DM,which may provide a research basis for the development of drug therapy for fatty liver or metabolic syndrome in the future.