| Objective: To investigate the correlation of dyslipidemia with left ventr icular systolic function and left ventricular mass index in elderly patients with hypertension.Methods: Select elderly hypertension patients from December 2017 to October 2019 who was given treatment at the Hypertension Center of the Heart Clinic of the First People's Hospital of Yinchuan,and a total of 250 case data were included,age 65 to 80 years old.The subjects were divided into 132 LDL-C normal group(LDL-C< 3.37mmol/L),79 cases in the LDL-C abnormal group(3.37mmol/L?LDL-C< 4.11mmol/L),39 cases in the LDLC elevation group(LDL-C? 4.11mmol/L)according to the levels of low-density lipoprotein cholesterol in blood lipids.The general clinical data and the left ventricular eject fraction(LVEF)and left ventricular mass index(LV MI)of the three groups were compared with the differences,and the correl ation between LDL-C with LVEF and LVMI was analyzed.Result:1.Comparison of general data and LVMI in LDL-C normal group?LDL-C abnormal group and LDL-C elevation group.Total cholesterol and LDL cholesterol were higher in LDL-C abnormal group and elevated group than in LDL-C normal group(P<0.05).In addition,glutamate aminotransferase in LDL-C elevated group was significantly high er than that in LDL-C normal group(P<0.05).But there was no difference in sex,age,height,body weight,body mass index,smoking,drinking,ACEI/ARB,beta blockers,CCB and diuretics,hypertension,glucose,triglyceride,high-density lipoprotein cholesterol,aspartate aminotransferase,urea and creatinine(P>0.05).In the comparison of echocardiography indexes,the LDLC elevation group was significantly higher than the LDL-C normal group in pulmonary artery diameter,ventricular septum thickness,left ventricular post erior wall thickness,left ventricular mass and LVMI(P<0.05),the LDL-C elevation group was significantly lower than the LDL-C normal group and the LDL-C abnormal group in LVEF(P<0.05),the other cardiac indexes don't have significant differences(P>0.05).2.Analysis of correlation between LDL-C and other factors with LVMIUsing LVMI as a dependent variable and the rest as independent variables for single factor correlation analysis,the results showed that hypertension grade(r=0.138,P=0.029),TC(r=0.166,P=0.009)and LDL-C(r=0.421,P<0.001)were positively correlated with LVMI,while sex(r=-0.235,P<0.001),ACEI/ARB medication history(r=-0.152,P=0.016)and LVEF(r=0.223,P<0.001)were negatively correlated with LVMI.Next further linear regression,after adjusting for other covariates the results suggested that LDL-C(r=0.413,P<0.001)was still positively correlated with LVMI,while sex(r=-0.209,P<0.001)and LVEF(r=-0.155,P=0.006)were negatively correlated with LVMI.The correlation that history of ACEI/ARB,TC and grade of hypertension with LVMI were disappear.3.Analysis of correlation between LDL-C and other factors with LVEFUsing LVEF as a depen dent variable and the remaining indexes were used as independent variables for single factor correlation analysis.The results showed that hypertension grade(r=-0.157,P=0.013),LDL-C(r=-0.177,P=0.005),TC(r=-0.211,P=0.022)and LVMI(r=-0.223,P<0.001)were negatively correlated with LVEF.Further multivariate linear regression,the results suggested that LDL-C(r=-0.169,P=0.007),hypertension grade(r=-0.140,P=0.007)and LVMI(r=-0.211,P=0.001)were negatively correlated with LVEF a fter adjusting for other covariates.The correlation that TC with LVEF were disappear.4.The influence factors of the LVHUsing LVH as the two-class variable and the remaining indicators as the covariates,the binary logistic regression analysis showed that LDL-C(OR=3.820)was a LVH risk factor.Conclusion:1.In senile hypertension patients of this study,female and elevated LDL-C can lead to elevated LVMI.2.In senile hypertension patients,with LDL-C levels increased and the severity of hypertension increased will have a relatively low LVEF.3.LDL-C is a risk factor of LVH. |
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