Prevalence And Risk Factors For Helicobacter Pylori Infection In Fuzhou Based On The Study Of Health Examination

Objective:To investigate the current prevalence and the peculiarity of H.pylori infection in Fuzhou,and explore the potential risk factors for H.pylori infection.And the strategies for the health management,prevention and cure for H.pylori infection can be developed.methods:There were two parts of the materials.The first part was based on the hospital current investigation.This study included subjects who received a ¹³C-urea breath test for H.pylori infection in a certain top three general hospital of Fuzhou from December 2016to June 2018.The‘Epidemiological Questionnaire of Helicobacter pylori infection',the Multicenter studies of Helicobacter pylori infection in China subject from Health management branch which in the Institute of Health Policy and Management China Health Promotion Foundation was applied for investigation and assessment.Data regarding infection condition of H.pylori infection,demographic factors and family information were collected.Data analyses were performed using SPSS software.The second part was based on the study of the personnel aged?20 years,who received a 13C-urea breath test in the physical examination center of the certain provincial general hospital of Fuzhou from December 2016 to June 2018.The?2 test,t test,variance analysis and logistic regression analysis?Wald backward model?was used to analyze factors related to H.pylori infection in Fuzhou.And the physical factors?blood pressure,BMI,waist-hip ratio?and clinical laboratory index?routine blood tests,liver function,renal function,blood lipid,blood glucose?were tested by professional staff from hospital.Results:The first part of the materials included 1059 subjects aged from 8 to 82 years,the mean age was 38.5±12.2 years with a median age 38.0 years.The prevalence of H.pylori infection was 50.8%,with 538 subjects positive in the 13C-urea breath test.Of the 542males,270?49.8%?were positive in the test,and of the 517 females,286?51.8%?were positive.There was no statistical significance?P>0.05?between males and females groups.The prevalence of H.pylori infection was different in age groups,40.8%was positive in the?20 years group,that was the lowest one among the age groups.And the50-59 years group had the highest prevalence,the prevalence from high to low was:50-59 years group,?60 years group,40-49 years group,20-29 years group,30-39 years group,and<20 years group.There was no statistical significance?P>0.05?among age groups.The prevalence of H.pylori infection was relatively higher in the group with education background of grade school and below,group with unemployed status,and group with monthly family income less than 1000 yuan.But there was no statistical significance?P>0.05?in the prevalence among age,race,marital status,literacy,career,family members average income,and family members groups.1010 subjects were enrolled in the second part of the materials.Univariate analyses were performed to evaluate risk factors of H.pylori infection,such as demographic and sociological characteristics,tumor history,family history,diagnosed disease or abnormity,operation history,gastrointestinal discomfort,medication history,infection of H.pylori,dietary habit,smoking history,drinking alcohol history,drinking history,daily life status,anthropometric index,clinical laboratory index.The following ones were significant risk factors of H.pylori infection:diagnosed disease or abnormity,gallbladder stone,halitosis,long-term medication history,H.pylori infection of spouse,daily alcohol consumption,blushing immediately after drinking,and duration of drinking?P<0.05?.In addition,chronic gastritis,PLT and daily sleeping time had statistical significance in the univariate analyses?P<0.10?.The binary regression analyses were performed with Wald backward model to evaluate independent risk factors which the P-value was less than 0.10.And the results showed H.pylori infection was significantly associated with duration of drinking?AOR=0.97,95%CI=0.94-0.99?,long-term medication history?AOR=1.84,95%CI=1.20-2.83?,halitosis?AOR=2.03,95%CI=1.27-3.24?,alcohol consume 50-100grams each time compared with no alcohol consumption?AOR=0.33,95%CI=0.15-0.70?,alcohol consume more than 250 grams each time compared with no alcohol consumption?AOR=0.32,95%CI=0.14-0.71?,sleeping 5-7 hours daily compared with 5 hours?AOR=6.09,95%CI=1.56-23.86?,sleeping 7-9 hours daily compared with5 hours?AOR=4.85,95%CI=1.34-17.33?.Conclusion:The prevalence of H.pylori infection in Fuzhou was lower than that in the nation with the characteristics:male had a peculiarity compared to female;50-59 years group had the highest peculiarity;and education background of grade school and below,unemployed,and monthly family income less than 1000 yuan had higher prevalence.The results of this study showed that long-term duration of alcohol,halitosis and long-term medication history were independent risk factor for H.pylori infection,Intake of alcohol50-100g or more than 250g each time would reduce the infection;Sleeping 5-7hours or more everyday might have resulted in the lower rates of H.pylori infection.Medical staffs should increase awareness of,and pay more attention to the current status.Then the targeted health management would be taken to control the infection.