Effect Of Epidural Anesthesia For Labor Analgesia On The Level Of Hypoxia Inducible Factor-1α In Umord Blood

Objective:To evaluate the effect of epidural labor analgesia on hypoxic-inducible factor-1α(HIF-1α)content in neonatal umbilical arterial blood.Methods:Sixty-four healthy singleton primiparas were selected.According to the principle of voluntary epidural labor analgesia,30 patients in the analgesic group(E)and 34 patients in the control group(C).Group E: When the cervix dilation was opened to 3 cm,epidural puncture was performed in the L2-3 intervertebral space,and an epidural catheter was placed and connected to an analgesia pump.Group C: Voluntary abandonment measures were taken and treated according to normal natural delivery procedures.The analgesic effect of the two groups of women(using the Mulleetr analgesia intensity score),the umbilical arterial blood flow S/D value at different stages of labor,the neonatal Apgar score,and the umbilical arterial blood gas were measured.The ELISA method was used to determine the level of HIF-1α in the umbilical artery.Results:The scores of Mulleetr of the group E were obviously lower than group C.There was no significant difference in the S/D values of the umbilical arterial blood flow between the two groups.There were no significant differences in Apgar score,arterial blood gas and HIF-1α results.Conclusion:The effect of low concentration local anesthetics combined with low dose opioid analgesics on epidural analgesia was definite,and there was no significant differences in Apgar score,umbilical arterial blood gas analysis and HIF-1 α results.