| Objective To explore the clinical characteristics of patients with systemic lupus erythematosus and pulmonary thromboembolism.Methods From January 2009 to January 2019,42 patients with SLE combined with PTE were screened from the patients hospitalized in the General Hospital of Ningxia Medical University,and 243 patients with SLE and without PTE were hospitalized in the same periodby means of isometric sampling.The clinical data and prognosis of the patients were recorded in detail,and the clinical characteristics of the two groups were analyzed and summarized retrospectively.Results1.There were 42 cases in SLE combined with PTE group,4 males and 38 females,male:female:1.00:9.50,with an average age of 45.52±13.25 years old,243 cases in SLE group,24males and 219 females,male:female:1.00:9.13,with an average age of 40.53±12.96 years old.The age in SLE combined with PTE group was significantly higher than that in SLE group(t=2.300,P=0.022),and the predisposing age was 50-60 years old;SLE patients with onset age≥50 years were more likely to have PTE(?~2=4.968,P=0.026).There was no statistical difference between the two groups in ethnicity and gender.2.PTE was more likely to occur in the course of SLE within 1 year(Z=-2.500,P=0.012).3.The disease activity of SLE combined with PTE group was higher than that of SLE group(Z=-2.896,P=0.004).4.The respiratory manifestations(dyspnea,chest pain,hemoptysis)and lower limb manifestations(swelling and pain)in the first symptoms of admission in the SLE combined with PTE group were significantly higher than those in the SLE group(?~2=36.062,P=0.000;?~2=4.012,P=0.045).5.White blood cells,neutrophils,uric acid,cholesterol,APTT and d-dimer in SLE combined with PTE group were higher than those in SLE group(Z=-2.904,P=0.004、Z=-3.805,P=0.000、Z=-2.033,P=0.042、t=2.089,P=0.042、Z=-2.201,P=0.028、Z=-3.994,P=0.000).However,albumin was lower than SLE group(t=-2.168,P=0.031).In the routine urine examination,the proportion of proteinuria in the SLE combined with PTE group was higher than that in the SLE group(?~2=5.866,P=0.015).There was no statistical significance in the lymphocytes,hemoglobin,platelets,globulin,creatinine,creatine kinase,triglyceride,high density lipoprotein,low density lipoprotein,urinary erythrocyte,urinary leukocyte,urinary duct typeurbc.6.ESR and CRP in SLE combined with PTE group were higher than those in SLE group(t=2.210,P=0.028、Z=-5.878,P=0.000).7.The IgG of SLE combined with PTE group was lower than that of SLE group(Z=-1.990,P=0.047).There was no statistical significance in complement(C3,C4),IgM,IgA,dsDNA,anticardiolipin antibody,ANCA,ANA,and ENA(anti Sm antibody,anti U1RNP antibody,anti SSA antibody,anti SSB antibody,anti Rib,anti Jo-1 antibody).8.The incidence of pulmonary arterial hypertension,pulmonary artery widening,pleural effusion,pericardial effusion,lower extremity thrombus,infection,hypertension and antiphospholipid syndrome was higher in SLE combined with PTE group(?~2=6.366,P=0.012、?~2=17.360,P=0.000、?~2=46.051,P=0.000、?~2=10.081,P=0.001、?~2=16.176,P=0.000、?~2=53.446,P=0.000、?~2=5.573,P=0.018、P=0.000).9.Hormone dose taken before admission in SLE patients had an effect on the occurrence of PTE(Z=-2.138,P=0.032).10.The length of stay in SLE combined with PTE group was longer than that in SLE group(Z=-3.107,P=0.002).11.There was no significant difference in the time of PTE in SLE patients under different treatment measures(F=1.608,P=0.216).12.Using logistic regression analysis,we found that age,SLEDAI score,white blood cells,APTT,d-dimer and CRP were risk factors for PTE in SLE patients.Conclusion1.PTE is more likely to occur in SLE patients with older,disease course within 1 year and severe disease activity.2.PTE is easy to occur in SLE patients with pulmonary artery widening,pulmonary hypertension,pleural effusion,pericardial effusion,lower extremity thrombosis,hypertension,infection and secondaryantiphospholipid syndrome.3.Age,SLEDAI score,white blood cells,CRP,APTT,and d-dimerwere risk factors for PTE in SLE patients. |
PDF Full Text Request