| Objective:Along with the improvement of economic and living standards,diet structure of people has changed.Diabetes mellitus(DM)and obese people are increasing year by year.It not only has brought the economic burden but also more threat to the health of human.Type 2 diabetes mellitus(T2DM)with obese people,who are having a bad diet,leading to blood free fatty acids(FFAs)changed.In recent years,the relationship between free fatty acids and insulin resistance(IR)has attracted much attention.Relevant research data have shown that total free fatty acid is positively correlated with insulin resistance,but correlation analysis of other free fatty acids is still lacking.In order to further understand the blood free fatty acid profiling in patients with type 2 diabetes and the correlation between insulin resistance and the possible risk factors of insulin resistance,we decide to have a study about it.We analysis of the patients with type 2 diabetes who individed into group with different body mass index(BMI)in blood free fatty acid spectrum and the relationship between it and insulin resistance.We hope that this thesis can provide the healthy diet guidance with diabetes patients,delay the onset of diseases,reduce the complications and help the patientis improve the prognosis and the quality of their life.Methods:Selecting the people who have a visit in China Japan union hospital of Jilin University during September 2018 to January 2020.The composition of control gruop includes 29 cases who are healthy people.And the 72 cases of T2 DM patients who from endocrine metabolism outpatients and the inpatients who meet the requirements of diagnosis as the research objects and individe into 3 group.According to BMI,they divided into the normal weight group(lean group,18.5 kg/m2 < BMI < 24 kg/m2,23 cases),overweight(BMI or less overweight group and 24 kg/m2 or less 28 kg/m2,23 cases)and obesity group(obsity group,BMI > 28 kg/m2,26 cases).Demographic information of the subjects was recorded: gender,age,height,weight and BMI.General biochemical indicators: Triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),fasting plsma insulin(FINS)and FFAs.The insulin resistance index(HOMA-IR)was calculated for each group,and the differences in demographic data,general biochemical data and blood free fatty acids profiling were compared among the four groups.SPSS22.0 software package was used for statistical processing,and difference analysis was used for calculation among different groups.P < 0.05 indicated statistical significance.The multiple linear regression model was used to explore the influencing factors of HOMA-IR.Results:1.The results of demographic data and general biochemical data show that some indicators are different between healthy people and patients with type 2 diabetes.The indicator include body mass index,glycosylated hemoglobin,fasting insulin,the steady-state model of insulin resistance index.They are different in the four groups with statistical significance(P < 0.05).And the steady state model of insulin resistance index has increased in patients with BMI.2.The results of blood free fatty acids profiling showed that there were statistically significant differences in the FFAs indexes of palmioleic acid,palmitic acid,wasabi and total fatty acid between healthy and type 2 diabetic patients(P<0.05).Palmitic acid,arachidic acid,fasting glucose and triglyceride were correlated with insulin resistance index in the steady-state model,and palmitic acid had the most significant correlation with insulin resistance index in the steady-state model.Conclusion:1.The level of palmitoleic acid in patients with type 2 diabetes was lower than that in normal people,while the level of palmitoleic acid,the level of wasyu acid and total fatty acid were higher than that in normal people.In addition,compared with normal weight and overweight patients with type 2 diabetes,the level of palmitic acid,yushi and total fatty acid were significantly increased in obese patients with type 2 diabetes.2.Increased the level of palmitate acid and decreased the level of arachidic acid are risk factors for increased insulin resistance in type 2 diabetes.Increasing level of palmitate acid leads to the most significant insulin resistance. |
PDF Full Text Request