An Analysis Of Polymorphisms Of Human Manganese Superoxide Dismutase Gene In A Sample Of 49 , Attempting To Detect Its Prediction Of The Breast Cancer Risk In HRT

background and Objective:Someone who are in the state of Premature loss of ovarian function in perimenopausal or postmenopausal women,suffer from the influence of Estrogen deficiency,including the physical and psychological symptoms in a short term,the osteoporosis,the cardio-cerebrovascular disease,and the atrophy of Genitourinary system.The hormone replacement therapy(HRT)can obviously relieve this symptoms and diseases,but maybe we pay attention to its risk of breast cancer and other.Because of the potential risk of HRT,an indicator that can effectively predict and evaluate the risk of breast cancer is urgently needed in clinical application.polymorphisms of human manganese superoxide dismutase gene is closely related to breast cancer.In order to study the distribution of polymorphisms of human manganese superoxide dismutase gene in normal female population,some women were selected on a voluntary basis to MnSOD gene polymorphism screening in this study.further,The subjects were divided into the HRT group and the control group according to the HRT treatment principle and the voluntary principle,followed up to observe the incidence of breast cancer in the two groups to preliminarily explore whether MnSOD gene polymorphism could predict the risk of breast cancer in HRT.Methods:49 women of health who voluntarily participated in polymorphism of MnSOD gene screening from March 2017 to December 2019 in the first affiliated Hospital of Nanchang University were selected as the study subjects.According to the principles of incorporating and a voluntary basis,the study subjects divided into two groups,HRT Treatment group and control group.All participants’ ages,BMI,menstruating age,smoking and alcohol history,breast cancer,family history,marital status,pregnancy history,breast-feeding time,hormone use,time and dose use,menopausal status,perimenopausal symptoms and mammary gland disease incidence etc will be counted so that can Statistical analysis.Results:1.The 49 participants who were divided into the HRT treatment group and the control group are not remarkable difference in statistics about The general conditions,Except for the statistical difference in age.MnSOD genotype and population distribution in this groups were examined by c 2(P(29)0.05),showing no statistical difference.2.The HRT group and the control group were followed up on an annual basis.By December 2019,There were 3 cases of new breast hyperplasia in the HRT group and no new breast cancer cases of all.3.In the HRT group,There are 4 participants who had been using HRT for more than 6 years and the MnSOD genotype was Val/Val,and three of them were diagnosed cyclomastopathy but not new breast cancer.Conclusions:1.HRT was positively correlated with breast hyperplasia with the duration of use.2.Preliminary results suggested that HRT did not increase the incidence of breast cancer with MnSOD Val/Val type.