Clinical Observation On Treatment Of Hp-related Chronic Erosive Gastritis(Damp-heat Syndrome Of Spleen And Stomach) By Jiedu Huashi Decoction

Research purposes:To explore the clinical efficacy of Jiedu Huashi Fang in the treatment of Hp-related chronic erosive gastritis（spleen and stomach dampness syndrome）.Research methods:A total of 72 cases with HP related chronic erosive gastritis（spleen stomach damp heat syndrome）from January 2019 to December 2019 in the digestive department of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine were collected.According to the order of treatment,72 cases were divided into observation group and control group,36 cases in each group.The observation group was treated with Jiedu Huashi formula combined with triple therapy（Jiedu Huashi formula,rabeprazole enteric coated capsules,metronidazole tablets,clarithromycin sustained-release tablets）;the control group was treated with bismuth quadruple therapy（compound bismuth aluminate granules,rabeprazole enteric coated capsules,metronidazole tablets,clarithromycin sustained-release tablets）;both groups took 14 days as a course of treatment.The data of cases were recorded and scored in detail.The database was established by Excel,and the data were processed by spss21.0 software.The HP eradication rate,clinical symptoms and clinical efficacy of endoscopic mucosal manifestations were analyzed and compared between the two groups.Research result:1.During the treatment,4 patients were excluded according to the elimination criteria due to drug allergies or lost to follow-up.A total of 68 patients met the criteria,34 in the observation group and 34 in the control group.According to the data analysis,Hp-related chronic erosive gastritis（spleen and stomach dampness syndrome）is less related to gender,and is more likely to occur in young and middle-aged people.The course of disease is mostly less than 5 years.2.At the end of the course of treatment,¹³C urea breath test was performed one month after drug withdrawal.The HP eradication rate of the observation group was 81%,while that of the control group was 84%,P>0.05.It was suggested that the HP eradication rate of the observation group was not significantly different from that of the control group,and the HP eradication effect of the two groups was similar.3.The total effective rate of the observation group was 88.24%,while that of the control group was 82.36%,P>0.05,indicating that there was no significant difference in the overall efficacy between the two groups.4.After treatment,the total symptom score of the two groups decreased compared with that before treatment（P<0.05）,and the total symptom score of the observation group was lower than that of the control group（P<0.05）,indicating that both groups can improve the clinical symptoms,and the effect of the observation group in improving the overall clinical symptoms is better than that of the control group.5.After treatment,the symptom scores of the observation group and the control group decreased compared with those before treatment（P<0.05）,suggesting that the observation group and the control group can improve the clinical symptoms of patients.6.By rank sum test,after treatment,the symptom scores of"stomach fullness"and"stool sticking"in the two groups were compared,P<0.05,which indicated that the observation group was more prominent than the control group in improving the symptoms of"stomach fullness"and"fecal adhesiveness";the symptom score ratio of"stomachache","burning stomach","heavy body","bitter mouth","bad breath"and"little food and appetite"were more prominent in the observation group than in the control group Compared with the control group,P>0.05,indicating that there was no significant difference between the observation group and the control group in the treatment of"stomachache","heartburn","heavy body","bitter mouth","bad breath"and"little food".7.The total effective rate of the observation group was 97.06%,and that of the control group was 88.24%,P<0.05,indicating that the curative effect of the observation group was better than that of the control group.8.After treatment,the scores of mucosal performance under gastroscope in the two groups were decreased compared with those before treatment（P<0.05）,indicating that the treatment schemes of both groups were effective.After treatment,the scores of mucosal performance under gastroscopy in the observation group were lower than those in the control group（P<0.05）,indicating that the effect of improving gastric mucositis in the observation group was better than that in the control group.Research conclusion:The HP eradication rate and clinical comprehensive efficacy of Jiedu Huashi Decoction Combined with triple therapy in the treatment of HP related chronic erosive gastritis（spleen and stomach dampness syndrome）are similar to that of bismuth quadruple therapy,which can better improve gastric mucositis and clinical symptoms.