Clinical Observation On The Treatment Of Spleen And Stomach Damp-heat Hp-related Chronic Non-astrophic Gastritis With Sanguisorba Capsules Combined With Triple Therapy

ObjectiveThis study summarized the current literature on the diagnosis and treatment of Helicobacter Pylori（Hp）-related chronic non-atrophic gastritis（CNAG）at home and abroad,and compared the traditional Chinese medicine Sanguisorba combined with triple therapy with bismuth.The clinical efficay and safe of triple therapy in the treatment of stomach damp-heat Hp-related CNAG patient,aim to exploring a new combination that could significant improving eradication rates of Hp,reduce the recurrence rate,obvious symptom relief,definite curative effect,and fewer adverse reactions.MethodsA total of 80 patients with CNAG who were treated in the outpatient department of Qingyuan Hospital from March 2019 to March 2020 were include in project.Randomly divided into groups（40 cases）.The treatment group was treated with Sanguisorba capsules+standard triple antibacterial treatment（esomeprazole+amoxicillin+clarithromycin）×14 days;control The group received standard triple antibacterial therapy（esomeprazole+amoxicillin+clarithromycin）for 14 days.Both groups of patients were rechecked for ¹³C or ¹⁴C breath test after stopping the drug for 1 month.Comparison of the Hp eradication rate,gastroscopy performance and Helicobacter pylori,TCM symptom score before and after treatment,and Hp relapse rate after six months of treatment compared between two groups.Use SPSS 22.0 software for statistical analysis,and conduct a comprehensive and objective analysis and evaluation of the recorded data.ResultsComparability analysis:A total of 79 study subjects included in this study（1 patient in the control group who withdrew from the study due to adverse drug reactions required other drug interventions other than this study,and was treated as shedding）in terms of gender,age,and course of disease After comparing the scores of various TCM syndromes before treatment,it was found that the differences between the groups were not statistically significant（P>0.05）,and they were comparable.Clinical efficacy analysis:（1）Hp eradication rate:In the experiment,both groups achieved good Hp eradication rate.But Hp eradcation rates of treatment groups is（87.50%）Is higher than the control group（84.62%）.（2）Efficacy of gastroscopy:The degree of gastric mucosal inflammation and Helicobacter pylori infection was understood through gastroscopy.The study found that both groups could significantly improve gastric mucosal inflammation,with no significant different.（3）The overall curative effects of TCM symptoms:From the analysis,the apparent efficiency of treatment group（67.50%）after treatment was significantly higher than that of control group（41.03%）.（4）TCM syndrome total scores:The score of two group of patient before treatment were compared.The treament groups were compared with totally sore of TCM symptom decreased more significantly（P<0.05）.（5）TCM symptom single points:After treatment,patients in the treatment group have symptoms such as gastric pain or dull pain,heartburn,belching,noisy sourness,heavy limbs,nausea and vomiting,poor appetite,dry mouth,bad breath or stickiness.The improvment is better than other.The control group has not different in the symptom relief of nausea and vomiting（P>0.05）.The other symptom indicators after treatment are compare with these before treatment.The contrast different was statisticaly signficant.（6）Hp recurrence rate:After six month following up,it is find that Hp recurrence rates of the treatment group（2.50%）is lower than other groups（5.13%）,and there is not difference between two groups.Safety analysis:Not serious abnormalities in liver and kidney function indexes before and after treatment in the two groups.One patient in the treatment group had symptoms of drooling and salivation after taking the medicine.Three patients in the control group had adverse reactions such as bitter mouth,slight dizziness,nausea,and diarrhea after taking the medicine.The patients with diarrhea withdrew from this clinical study due to their condition requiring drug interventions other than this study.The rest of the patients had their symptoms improved or disappeared after communicating and explaining to the patients and psychological counseling.ConclusionThe Chinese medicine Sanguisorba capsules combined with triple therapy used in this study can significantly reduce the total score of TCM syndromes and significantly improve the clinical symptoms of Helicobacter Pylori（Hp）-related chronic non-atrophic gastritis（CNAG）patients.Under the premise that the effect of improving gastric mucosal inflammation under gastroscopy is equivalent to that of triple therapy The eradication rate of Hp is better,the recurrence rate is lower,and the safety is better.The variability of traditional Chinese medicine in the process of differentiation and treatment,the diversity of medications,and the treatment of both symptoms and root causes fundamentally reduce the occurrence of drug resistance and adverse reactions,reduce the economic burden of patients,and improve patient compliance.It is a target for Hp-related CNAG patients The new ideal comprehensive treatment plan of Chinese and Western medicine.