The Short-term Curative Effect Observation Of Changji Prescription Combined With Capecitabine In The Treatment Of Elderly Patients With Colorectal Cancer (spleen Deficiency And Blood Stasis Type)

Objective: To observe the clinical effect of intestinal accretion combined with ce Pecitabine in the treatment of advanced colorectal cancer(s Pleen deficiency and stssis)Methods: According to the criteria,42 cases were divided into observation group and control group according to random principle,each group was divided into21 cases,the observation group was treated with enterocortex combined capetabine chemothera Py,the control group was treated with simple capetabine chemotherapy for21 days,a total of 3 cycles.Objective: To observe the changes of solid tumor curative effect,TCM syndrome score,KPS score,immune index(CD3,CD4 CD8,NK cell activity ratio)and chemotherapy toxicity response index of the two groups.The data were analyzed using software SPSS 22.0.Results: 1.The recent curative effect of tumor in two groups after 3 weeks: 7cases were partially relieved,10 cases were stable,4 cases were not relieved or even advanced,the total remission rate was 81 %,6 cases were partially relieved in control group,10 cases were not relieved or even 5 cases were stable,the total remission rate was 76 %,and there was no significant difference between the two groups(P > 0.05).2.TCM Syndrome Scores: There were 19 Patients in the observation group who had improved(6 markedly effective and 13 effective).In the control group,there were 15 improved cases(2 markedly effective and 13 effective).There was a statistically significant difference between the two groups(P=0.048<0.05),TCM syndrome scores before and after treatment were statistically significant(P<0.01).3.KPS score:In the observation group,there were 19 cases with improvement(7 cases markedly effective,12 cases effective),and 14 cases with impovement in the control group(3cases markedly effective and 11 cases effective).The comparison between the two groups was statistically significant(P=0.042 <0.05),KPS scores before and after treatment in both groups were statistically significant(P<0.01);4.Immune index(CD3,CD4/CD8,NK cell activity ratio): The observation group had an increase compared with before treatment,the difference was statistically significant(P<0.05),but the control group decreased,statistical analysis had no difference(P>0.05)Thedifference between the two groups after treatment(P<0.05)was statistically significant.5.Chemotherapeutic drug toxicity response index(gastrointestinal response,bone marrow inhibition,abnormal liver and kidney function,hand and foot synthesis): The incidence of treatment group and observation group(P > 0.05),the difference is statistically significant.Conclusion:Although the combination of the enteric formula with Capecatabine and Capecatabine alone can not completely eliminate the tumor,the two treatments can stabilize some patients,improve the TCM syndrome score and the card score,and the combination of the intestinal formula with Capecatabine is superior to simple chemotherapy in improving the TCM syndrome score and the card score,and can improve the quality of life and the body immunity.It is worth further study to reduce the toxicity of Capecatabine.