| Objective:To compare the incidence and related factors of DKD diagnosed by three methods of e GFR,UACR,e GFR combined with UACR.Methods: A total of 1254 Patients with T2 DM were enrolled and divided into the DKD group and DM alone group according to three methods.age,duration,systolic blood pressure(SBP),body mass index(BMI),direct bilirubin(DBIL),hemoglobin(Hb),albumin and other indicators were recorded as well.The incidence of DKD was calculated.Multiple Logistic regression analysis was conducted to analyze the related factors of DKD.Results: The incidence of DKD were 15.9%,33.9% and 38.7% under three diagnostic methods: e GFR,UACR,and e GFR combined with UACR.The age,duration and SBP in the DM alone group were significantly lower than in the DKD group(all P<0.05).Multiple Logistic regression analysis showed that SBP,BMI and duration were independent risk factors of DKD(OR>1,P<0.05);Hb and albumin were protective factors of DKD(OR<1,P<0.05)diagnosed by the method of e GFR.Under the diagnostic method of UACR,age,SBP,BMI and duration were independent risk factors of DKD(OR>1,P<0.05);DBIL was protective factor of DKD(OR<1,P<0.05).For the diagnostic method of e GFRcombined with UACR,age,SBP,BMI,duration and triglyceride were independent risk factors of DKD(OR>1,P<0.05);DBIL,Hb and albumin were protective factors of DKD(OR<1,P<0.05).Conclusions: Compared with the other two diagnostic methods,e GFR combined with UACR has the highest diagnostic rate in diagnosing DKD,which can increase the detection rate and find more related factors of DKD.Objective: To explore the relationship between chronic low-grade inflammation and DKD.Methods: A total of 1254 Patients with T2 DM were enrolled and divided into two groups : DKD group(487cases)and DM alone group(767cases).DKD was diagnosed if the estimated glomerular filtration rate(e GFR)were less than 60 m L/(min·1.73m2)or if the urinary albumin to creatinine ratio(UACR)were no less than 30mg/g.Serum chronic low-grade inflammation indexes including high sensitive C-reactive protein(hs-CRP),total white blood cell count(WBCC)and neutrophil percentage(NCR)were measured with an automatic analyzer: Sex,duration,systolic blood pressure,diastolic blood pressure and other indicators were recorded as well.Multiple Logistic regression analysis was conducted to analyze the relationship between chronic low-grade inflammation indexes and DKD.Results: The hs-CRP,total white blood cell count and NCR were significantly higher in DKD group than those in DM alone group(t=-3.60、-3.43、-3.10,all P<0.01).Multiple Logistic regression analysis showed that hs-CRP(OR=1.116,95%CI:1.042~1.195,P=0.002),total white blood cell count(OR=1.092,95%CI:1.002~1.189,P=0.044)and NCR(OR=1.018,95%CI:1.004~1.033,P=0.015)were related to increased risk of DKD.Conclusions: Chronic low-grade inflammation indexes are increased in DKD.Moreover,hs-CRP,total white blood cell count and NCR are independent risk factors of DKD.Objective: To evaluate the risk and related factors for kidney disease progression in hospitalized patients with T2 DM according to combined UACR with e GFR.Methods: A total of 1254 Patients with T2 DM were enrolled and divided into four groups according to the KDIGO guidelines: low risk group,moderately increased risk group,high risk group and very high risk group.The ratio of patients in each group was calculated and the clinical parameters were compared.Results: The risk of kidney disease progression in hospitalized T2 DM patients is low risk group(61.3%),moderately increased risk group(24.6%),high risk group(7.4%)and very high risk group(6.7%).Age,duration and SBP were the related factors of kidney disease progression(P<0.05).Conclusions: The rate above the moderately increased risk for kidney disease progression in hospitalized cases with T2 DM was 38.7%,and age,duration and SBP were related to kidney disease progression. |
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