The Clinical Study Of Liqi Ningshen Decoction In The Treatment Of Insomnia Due To Stagnation Of Liver And Qi

OBJECTIVE:With the increase of life pressure,the number of insomnia in China wil-1 increase,and the long-term sleep disorder will affect the quality of personal life.At the same time,it will lead to a series of physical and mental diseases,which are ins-eparable from the occurrence of hypertension and obesity.The experience of predeces-sors and combined with my teacher years of clinical medication experience,summed up Liqi Ningshen formulation has a good effect in the treatment of patients with liver stagnation and qi stagnation insomnia.In order to objectively evaluate the clinical eff-icacy and safety of Liqi Ningshen formulation intervention in the treatment of patient-s with liver stagnation and qi stagnation insomnia,and to observe the improvem ent o-f abnormal emotions associated with insomnia patients,.A clinical randomized controll-ed trial was done.METHODS:The patients were from insomnia outpatients at Dong zhi men Hospital.We collected information of insomnia patients who visited the instructor’s clinic during the period from December 2017 to June 2018,and selected insomnia that met the sy-ndrome of liver stagnation and qi stagnation.A total of 64 subjects who met the incl-usion criteria were enrolled,and were randomly divided into groups by random numb-er table and random number remainder grouping.The Chinese medicine group(group A)was treated with the Chinese medicine granules added by Liqi Ningshen formulati on.The western medicine group(Group B)was treated with zopiclone tablet.The test continued for a total of 4 weeks.The general condition,vital signs,Pittsburgh sleep q uality index(PSQI),TCM syndrome scale,Self-Rating Anxiety scale;Self-Rating Depre-ssion scale were recorded at the beginning and end of the trial.The PSQI score and the comprehensive improvement rate of TCM syndrome scores were used to evaluate the clinical efficacy.The observation and analysis of the SAS and SDS scale reducti-on rates before and after the test were conducted to improve in the state of anxiety a-nd depression.The data obtained from the experiment were recorded by Excel softwa-re and processed by SPSS software version 20.0.The scores of PSQI score,TCM sy-mptom score and SAS and SDS scales of the two groups were statistically described by mean ± standard deviation,and the comparison between groups and groups was a-dopted.Corresponding T test or non-parametric rank test;clinical efficacy was expres-sed as a percentage,and chi-square test was used for comparison between groups;P<0.05 was considered statistically significant.RESULTS:After a 4-week trial,a total of 60 patients completed the whole course of treatment,of which half of the patients in the Chinese medicine group(group A)and half in the western medicine group(group B).After treatment,the clinical effective r-ate of both groups reached the expected level,93.33%in the Chinese medicine grou-p and 76.66%in the western medicine group.The clinical effective rate of the Chine-se medicine group was higher than that of the western medicine group,but it was n-ot statistically significant(P>0.05),suggesting that Chinese medicine and The clinical effect of western medicine in treating insomnia was quite similar.In the improvement of Pittsburgh sleep quality index:there was no significant difference in PSQI score b-etween the two groups before treatment(P>0.05).After treatment,the PSQI scores of the two groups were lower than before,and the difference between the same groups was significant(P<0.05),there was no significant difference between the two groups(P>0.05);In improving the TCM syndromes of patients:before treatment,the TCM sy-ndrome scores of the two groups were comparable(P>0.05),and the results showed t-hat,after treatment the Chinese medicine improved Insomnia patients with pharyngeal f-oreign body sensation,good traits,hiccups,mouth pain and anorexia have advantages compared with Western medicine group,the difference is statistically significant(P<0.05);In improving patients’ depression:before treatment,two groups The SDS scores were comparable(P>0.05).After treatment,the SDS scores of the two groups were 1-ower than before,and there were differences between the same groups(P<0.05).The depression effect was better than the western medicine group,the difference was stati-stically significant(P<0.05);In improving the patient’s anxiety:before treatment,the SAS scores of the two groups were comparable(P>0.05).After treatment,the two gro-ups of patients the SAS scores were lower than before,and there were differences in the same groups(P<0.05).There was no significant difference between the two grou-ps(P>0.05),suggesting that Ch:inese medicine and western medicine have the same ef-feet in improving patients’ anxiety.Conclusion:Liqi Ningshen Recipe is used to treat patients with liver stagnation and qi stagnation insomnia.Its clinical curative effect is considerable,no less than the clinic-al efficacy of western medicine zopiclone tablet,and it can significantly improve the TCM symptoms of patients with insomnia,and effectively alleviate the negative emoti-ons of patients.It is safe and has no adverse reactions.In general,its clinical effect i-s better than that of zopiclone.