Analysis Of TCM Syndrome Types And Influencing Factors Of Proinsulin And Type 2 Diabetes With Hyperuricemia

Purpose:To explore the relationship between proinsulin(PI)and type 2 diabetes mellitus(T2DM)combined with hyperuricemia,and explore the correlation between them,so as to provide references for clinical diagnosis and treatment.Material and method:The T2 DM patients randomly selected in the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine’s Department of Endocrinology from September 1,2016 to June 1,2017,were divided into T2 DM with hyperuricemia group(T2DM+HUA group)and T2 DM group(T2DMgroup)according to serum uric acid level.And the patients in the T2DM+HUA group TCM were analysised and divided into dampness heat syndrome,phlegm and blood stasis,deficiency of Qi and yin deficiency syndrome with two and two of yin and Yang Syndrome Type 4,according to the diagnostic data.PI and other related physiochemical indexes of all the patients were analyzed through the statistical methods,to explore the relationship between them.Results: 1 In the 4 syndrome types of T2DM+HUA group,the blood PI of the patients with phlegm and blood stasis syndrome was the most significant(P < 0.05).2 PI were positively correlated with waist circumference in T2DM+HUA group(P < 0.05).3 The level of PI in T2DM+HUA group was higher than that in T2 DM group(P < 0.05).4 Hyper blood PI was one of the risk factors of T2 DM combined with hyperuricemia(P < 0.05).Meanwhile,the duration of T2 DM,the increase of BMI and the decrease of HDL-C were associated with the increase of uric acid level(P < 0.05).Conclusion: 1 The relationship between Hyper blood PI and phlegm and stasis syndrome was closely related.PI may be related to the pathogenic factors "phlegm" and "stasis",and determined the evolution and outcome of each type of syndrome.2 T2 DM patients with hyperuricemia generally had obvious hyperlipidemia,which might be associated with insulin resistance and affect the formation and excretion of uric acid.3 PI was the risk factor of T2 DM combination with hyperuricemia.