A Study On TCM Symptom Type And Related Factors Of Type2 Diabetes Mellitus Complicated With Hyperuricemia

Objective: To study the related factors and TCM syndrome distribution of type 2diabetes mellitus complicated with hyperuricemia by analyzing the data of patients with type 2 diabetes mellitus complicated with hyperuricemia,so as to provide guidance for its treatment and syndrome differentiation.By collecting the relevant literature of traditional Chinese medicine in the treatment of this disease,carry out data mining,sum up the rules of drug use,and guide the clinical accurate use of drugs.Methods: The medical records of the study were selected from the Department of Endocrinology and Metabolism,affiliated Hospital of Changchun University of traditional Chinese Medicine from September 2018 to September 2021.A total of 150 eligible patients with type 2 diabetes complicated with hyperuricemia were included,and 150 eligible patients with normal uric acid in type 2 diabetes were randomly selected.The medical records of the two groups were statistically analyzed.Search the literature related to the disease and carry out data mining.Results: 1 There was statistical difference between the two groups,and the prevalence rate of males was higher than that of females.BMI,FCP,TC,TG,ALT,AST,GGT,SUA,Scr,Cys C,MAlb in T2 DM with HUA group were higher than those in T2 DM group,HDL-C and Lp(a)were less than T2 DM group,SBP,DBP,age,course of disease,FBG,Hb Alc,LDL-C had no statistical significance.2 Serum uric acid was negatively correlated with HDL-C and Lp(a),and positively correlated with male,BMI,FCP,TC,TG,ALT,AST,GGT,Scr,Cys C and MAlb.3 BMI,FCP,TC,HDL-C,GGT and Scr are the risk factors of type 2 diabetes mellitus complicated with hyperuricemia.4 In the type 2 diabetes with hyperuricemia group,the syndrome of dampness and heat trapping the spleen and the syndrome of blood stasis and venation had statistical significance.GGT was significantly higher in T2 DM combined with HUA syndrome of damp-heat stagnation of spleen than in other syndrome types.5 According to analysis,the top ten traditional Chinese medicines with the highest frequency of occurrence are: Bixie,Rhubarb,Poria cocos,Achyranthes bidentata,Coix seed,Tucia cocos,Alisma orientalis,Weilingxian,Salvia miltiorrhiza,Plantago seed;The frequency of occurrence of the four Qi types ranges from more to less: cold,calm,warm,slightly cold,slightly warm,cool,hot,and severe cold and heat.The frequency of occurrence of the five flavors ranges from more to less sweet,bitter,spicy,light,and sour.According to the frequency of occurrence,the meridians of the liver,spleen,stomach,lung,kidney,etc.were ranked,and the correlation analysis of the compatibility of traditional Chinese medicine was conducted.A total of 11 groups of associated traditional Chinese medicine combinations were obtained;Cluster analysis showed that the two groups of prescriptions were Dachaihu Decoction plus or minus and Liuwei Dihuang Decoction plus or minus Sijunzi Decoction.Conclusion: 1 The incidence of T2 DM with UA is related to gender,BMI,FCP,TG,TC,HDL-C,Lp(a),AST,ALT,GGT,Scr,Cys C,and MAlb;The risk factors for its onset are BMI,FCP,TC,HDL-C,GGT,and Scr.2 The syndrome of damp-heat trapping spleen and blood stasis and venation are more common in T2 DM patients with HUA,and GGT in the syndrome of damp-heat trapping spleen is more likely to increase.Therefore,when treating T2 DM patients,it is necessary to take care of the liver and gallbladder to prevent both diseases and changes.3 The core drugs for the treatment of T2 DM combined with HUA are Bixie,Rhubarb,Poria cocos,Achyranthes bidentata,Coix seed,Tuckahoea,Alisma orientalis,Weilingxian,Salvia miltiorrhiza,and Plantago seed.The main drugs are products that can dilute the penetration and remove dampness,clear the internal organs and relieve turbidity,nourish the liver and kidney,replenish qi and strengthen the spleen,and detoxify and diuretic.Cluster analysis shows that the prescription for the treatment of T2 DM combined with HUA is Dachaihu Decoction plus or minus,and Liuwei Dihuang Decoction plus Sijunzi Decoction plus or minus,both of which are consistent with the pathogenesis of T2 DM combined with HUA.4 In the treatment of T2 DM combined with HUA,the main properties of the drugs are cold and mild,and the main flavors are sweet,bitter,spicy,and mild.The meridians are mainly liver,spleen,stomach,and kidney.Therefore,this disease should be mainly treated from the perspectives of liver,kidney,and spleen and stomach.