Clinical Observation On The Topical Application Of Shirebitong Ointment In The Treatment Of Acute Gouty Arthritis With Damp-heat Arthralgia Syndrome

Objective:To observe the clinical efficacy and safety of ShiReBiTong cream applied externally in the treatment of damp-heat obstruction syndrome of acute gouty arthritis.Methods:Sixty patients with acute gouty arthritis who met the inclusion criteria were randomly divided into a treatment group and a control group according to the Doll’s table,with 30 cases in each group.The control group was educated 、 given diclofenac sodium sustained-release capsules and colchicine;the treatment group was given external application of ShiReBiTong cream on the basis of the control group.A course of treatment is7 days.After one course of treatment,the efficacy of TCM syndromes before and after treatment,joint symptoms(joint mobility,joint swelling,joint pain VAS score,affected skin temperature),Interleukin-6,Blood Uric Acid,Erythrocyte sedimentation rate,C-reactive protein and other indicators were used to evaluate the clinical efficacy of topical application of ShiReBiTong cream on dampness-heat obstruction syndrome of acute gouty arthritis.Results:1.External application of ShiReBiTong cream can improve the joint symptoms of patients with acute gouty arthritis damp heat and obstruction syndrome.After one course of treatment,the two groups of joint activity scores,joint swelling scores,VAS scores,and skin temperature Both were significantly lower than before treatment,and the treatment group were significantly better than the control group(P<0.05).The VAS scores and skin temperature of the affected area on the fourth day of treatment were statistically significant.The treatment group were better than the control group(P<0.05).2.Before treatment,the total scores of TCM syndromes of the two groups were tested by t test,t=0.628,P= 0.532> 0.05,there was no statisticaldifference,and they were comparable;after 7 days of treatment,the scores of TCM syndromes of the two groups decreased significantly,and the treatment group was excellent.In the control group(P<0.05).3.After 7 days of treatment,Blood Uric Acid,Interleukin-6,Erythrocyte sedimentation rate,C-reactive protein in the two groups were significantly reduced,and there was a statistical difference compared with before treatment(P<0.05);the comparison between the ESR,IL-6,and CRP groups suggested that the treatment group was better than the control(P<0.05).4.Comparison of the efficacy between the two groups,after the rank sum test Z=-2.329,P=0.02<0.05,the two treatments have different effects on acute gouty arthritis,and the treatment group is better than the control group;Effectiveness:96.70% in the treatment group and 83.33% in the control group.5.During the test,there were no obvious adverse reactions in the two groups,and there were no obvious abnormalities in various safety indicators.Conclusion:This study shows that external application of ShiReBiTong cream in combination with western medicine can effectively improve joint swelling and mobility in patients with acute gouty arthritis,reduce the pain of patient,reduce the temperature in the affected area,and has a better effect than oral western medicine alone.In addition,the ShiReBiTong cream is safe and effective,has a low price,carry and use conveniently,it is worth to be further promoted and applied.