Design, synthesis and solubility implications of large generation triazine dendrimers and dendritic nanocomposite

Dendrimers are versatile polybranched polymers that intend to exhibit monodispersity and globular shape at large generations. Their assembly is iterative in nature and involves multi-step synthesis. Dendrimers were first reported in 1985 by Tomalia and Newcome. The versatility of dendrimers is based on the possibility of controlling their dimensions and their capability of bearing a defined amount of cargo on the end point of their branches (multivalency), and even the property of storing some other smaller molecules inside them (Chapter 1).;High generation dendrimers display multiple challenges for their synthesis that involve solubility, structural defects and long times for their synthesis. Those are the main reasons that have allowed to just few designs of dendrimers to reach generation 9. After several years of exploration and understanding the reactivity of several amine linkers towards the chemeoselective substitution of cyanuric chloride, two different families of triazine dendrimers have overpassed generation 9 (Chapter 1).;Since the traditional methods of synthesis for large generation triazine dendrimers take months for their completion, a new synthetic approach was needed. Microwave assisted reactions were found to be the fastest route to reduce times of reaction for triazine dendrimers from months to just few hours (Chapter 2).;The rapid production of triazine dendrimers and their good water solubility, allowed us to explore diverse hybrid designs that provided insights about solubility and structural conformation of triazine dendrimers (Chapter 3). Also, the excellent water solubility properties of 4,7,10-trioxa-1,13-tridecanediamine based dendrons were used in the synthesis and stabilization of gold nanoparticles, that displayed homogeneity in solution for more than a year (Chapter 4).;Furthermore, blood clotting properties of triazine dendrimers were studied for possible solutions to bleeding disorders and a conceptual design of multifunctional prostate specific membrane antigen (PSMA) targeted dendrimers was pursued (Chapter 5).