Study On Preparation And Biocompatibility Of HAP/PEEK Composites Based On 3D Printing

In recent years,how to manufacture the customized implant components quickly and accurately has become a major issue in the field of orthopedic implant consumables,and 3D printing technology is popular in the field of bone implant materials because it can customize high-precision and high-complexity components which are difficult to prepare by traditional methods.Currently,PEEK,which has excellent mechanical properties and good chemical stability,is widely used in the field of bone implant materials.Also,HAP is very popular due to its nice osteoconductivity and biocompatibility.So,HAP/PEEK composite,which combines the advantages of the two components,has a good application prospect.In this paper,based on the preparation of n-HAP by co-precipitation method and the preparation of PEEK powder by nucleophilic substitution,the n-HAP/PEEK composite powders were prepared by changing the way of adding HAP,and prepared composite wires that can be used for FDM 3D printing by extrusion molding process,also successfully prepared intervertebral fusion cage products containing uniform pores of an average size of 800?m through FDM 3D printing.HAP/PEEK wires with 0wt%-15wt%HAP for FDM 3D printing were prepared based on the synthesis of 0wt%-30wt%HAP/PEEK powders.In the composite powders with HAP content below 10%,HAP existed as a single whisker with a length of 100-400nm and a width of 20-50nm.In 20%HAP/PEEK composite powders,nano HAP whiskers began to agglomerate in some areas.The melting point and initial decomposition temperature of the HAP/PEEK composite powders were about 340?and 500?,which were equivalent to PEEK.All composites did not exhibit cytotoxicity.The addition of HAP could increase the alkaline phosphatase activity,enhance the adhesion between materials and cells,and also effectively improve the ability of bone guidance of the composites.10%HAP/PEEK composite wire had the best comprehensive performance.It had high tensile strength(73.92MPa),hardness(45.57HBa)and the highest elastic modulus(2.65GPa).At the same time,the contact angle was greatly reduced to 62.2~o compared with PEEK(84.9~o),it had nice hydrophilicity.In addition,the composite did not exhibit cytotoxicity.It could promote the osteogenic differentiation of MG-63 cells and provided biocompatible surface for the cell attachment.In SBF solution,the composite could induce the apatite to deposit on the surface of the material rapidly,experimental results showed its strong bone connection ability.The 10%HAP/PEEK composite wire had strong mechanical properties and biocompatibility,and the intervertebral fusion cage containing uniform pores of an average size of 800?m was fabricated by FDM 3D printing,which had great potential in the field of bone implant materials.