Construction Of Fluorescent Probes For Phosgene And Nerve Agent And Investigation Of Their Properties

Phosgene and nerve agents are a class of highly toxic substances with high chemical reactivity,which pose great threat to public security and human health.Fluorescent probes have attracted researchers’ great attention due to high-sensitivity,convenience and fast analysis.In this thesis,three fluorescent probes were designed and synthesized to detect phosgene and nerve agents.The specific research contents include:1.A proportional fluorescence probe ETA-BDP based on BODIPY was designed and synthesized for rapid visual detection of phosgene.Phosgene is electrophilically coupled to the-NH-and-OH groups in ETA-BDP to form a five-membered lactam ring,which inhibits the intramolecular charge transfer effect and leads to a significant colorimetric and ratio fluorescence enhancement(～ 130 times).It demonstrates that ETA-BDP features good selectivity and sensitivity,low detection limit(16.5 n M)and fast response speed(< 3.0 min).Furthermore,ETA-BDP loaded polymer film was prepared to determine the phosgene in the gas phase.2.A phosgene fluorescent probe APAC with anthracenimide as the fluorophore and o-hydroxyaniline as the recognition group was designed and synthesized for the convenient real-time detection of phosgene.The OHA group contains ortho-disposed hydroxyl and amine groups for reaction with phosgene to produce the benzoxazolinonecontaining.The fluorescent probe has the advantages of fast response speed(15 s),high selectivity,visible color change visible to the naked eye,and extremely low detection limit(4.6 n M).In addition,a flexible paper-based chemical sensor was fabricated,which showed good performance in the visual detection of phosgene.3.In order to detect phosgene and nerve agent DCP simultaneously,a fluorescent probe PDAC with o-phenylenediamine as the recognition group and anthracenimide as the fluorophore was designed and synthesized.According to different responses,PDAC presents a significant emission of fluorescence in response to DPC at 588 nm.In comparison,PDAC undergoes amidation reaction with phosgene to generate benzoxazolinone,which generates a fluorescence-enhanced signal at 500 nm,which has the advantages of fast response(< 2 minutes),high selectivity and low detection limit(72 n M).Finally,a PDAC-loaded polymer film is produced and illustrate that the film is of practical significance in the detection of phosgene and DCP vapor.