Synthesis Of Quinazoline And Indanone Derivatives Based On C(sp~2)-H Functionalization

To date,we know of compounds containing carbon-hydrogen bonds on the order of tens of millions.It is the ideal of our researchers to synthesize these compounds containing C-H bonds into more valuable compounds by artificial transformation.C-H functionalization is the dissociation of C-H from a hydrocarbon and the recombination of other C-H or C-X(X=C,O,N,S,Si,P,etc.)into the target molecule.With the development of synthetic chemistry,various C-H functionalization strategies have been developed to construct C-C bonds.These include cross dehydrogenation coupling(CDC),which are in line with the Green Chemistry Initiative.For the substrate containing carbon-carbon bond and carbon-heterobond,C-C bond can also be constructed by decarboxylation coupling,dehalogen coupling and other methods.Based on the above background,this paper describes my two main work during my postgraduate period:(1)Amidoquinazoline derivatives were synthesized by three-component one-pot decarboxylation with ammonium persulfate as oxidant in the absence of transition metal and precious metal and photocatalyst.The reaction conditions are mild and can be carried out under air conditions.During the process,only hydrogen atoms,water and carbon dioxide and other environmentally friendly molecules are removed,and atomic economy is high.This strategy provides a new and effective method for the functionalization of quinazoline.(2)The indanone compounds were synthesized by visible light catalytic cross-dehydrogenation coupling strategy.The new C-C bond was constructed by cross-dehydrogenation coupling of the substrates,which has good atomic economy and conforms to the concept of green chemistry.In addition,the cycloether products synthesized by this method can be further hydrolyzed and condensed to obtain Indanone compounds which are widely used in medicine,providing a new method for the synthesis of these compounds.