Preparation And Properties Of Nitrogen-doped Carbon-based Adsorbent Drugs

The rapid economic development has led to an ever-increasing demand for human life.Human beings will become unhealthy under multiple pressures,which will lead to an increase in the types of diseases and incidences.Among them,the scope of antibiotic treatment is wide and effective,this makes it continuously expand in the field of medicine,and is widely used in the prevention and treatment of human diseases.At the same time,it has caused the residue of antibiotics in the human body.After consuming antibiotics,some of them will remain in the intestines,leading to imbalance of the flora and the emergence of resistant bacteria.Therefore,the development of carbon-based drugs that can absorb residual antibiotics in the stomach and prevent the local effects of antibiotics at the level of the colon has become a good way to reduce these side effects.This article mainly adopts the adsorption method with adsorbent as the key to prepare a carbon-based drug that can adsorb residual antibiotics in the colon or the back of the cecum.The carbon-based materials used to prepare carbon-based drugs have good adsorption properties and can be used as adsorbents.Therefore,it is necessary to develop a carbon-based material with strong adsorption capacity to meet the adsorption demand.Heteroatom-doped especially nitrogen-doped porous carbon have a higher specific surface area and richer pores,which can effectively adsorb antibiotics remaining in the stomach and intestines.In this paper,three carbon-based materials with different specific surface areas,nitrogen-doped and rich pores were prepared as adsorbents,which were used to investigate the adsorption performance of the adsorbate cephalexin.The main research contents are as follows:（1）Preparation of nitrogen-doped mesoporous carbon materials（NMC-x）and research the adsorption capacity for cephalexin solution:Due to metal organic framework（ZIF-8）has high specific surface area,rich microporous structure and high level of nitrogen doping,it has received extensive attention.The experimental process is the mixed reaction of ZIF-8 with resin and ethyl orthosilicate to obtain nitrogen-doped carbon material（NMC-x）.The 2-methylimidazole can provide a rich source of nitrogen and carbon.The synthesized NMC-1 has a specific surface area of 1 074 m² g^-1 and a nitrogen content of 10.8 at%.We also studied the adsorption performance of the NMC-1 on cephalexin solution.The study shows that when the initial concentration is 80mg·L^-1,its adsorption capacity gradually reaches saturation,and its adsorption capacity is as high as313.0mg·g^-1.（2）Preparation of high-nitrogen-doped tubular mesoporous carbon（HTMC）and research the adsorption capacity for cephalexin solution:the use of natural and economical kaolinite ore halloysite as a tubular template,and metal organic compound ZIF-8 as a carbon source to prepare high nitrogen-doped HTMC.HTMC exhibits a high specific surface area of 1 334 m² g^-1 and a high nitrogen content of 10.8 at%.We also studied the HTMC adsorption on cephalexin solution.The results showed that when the initial concentration was 80mg·L^-1,the adsorption capacity gradually reached saturation,and the adsorption capacity was as high as 338.7mg·g^-1.（3）Preparation of nitrogen-doped mesoporous carbon nanosheets（N-MCN-x）and research the adsorption capacity for cephalexin solution:In this part,Mg（OH）2 sheets as template,dopamine as nitrogen and carbon source,poloxamer F127（EO106–PO70–EO106）as a surfactant,1,3,5-trimethylbenzene（TMB）as porogen,through the polymerization of dopamine under alkaline condition conformation of nitrogen-doped mesoporous carbon sheets（N-MCN-x）.The results show that N-MCN-0.3 has a specific surface area as high as 1 760m²·g^-1,and the nitrogen content is 4.5at%,which has a higher nitrogen content.The experiment explored the adsorption performance and cycle stability of the N-MCN-0.3 adsorption on cephalexin solution.The results showed that the adsorption capacity gradually reached saturation at the initial concentration of 80mg·L^-1,and the adsorption capacity of N-MCN-0.3 was as high as353.1mg·g^-1.