Clinical Efficacy Observation Of SiJunZi Decoction Combined With JiaweiLiansuyin And Quadruple Therapy In The Treatment Of Hp Gastritis

Objective:To observe the clinical efficacy,safety and eradication of SiJunZi decoction combined with JiaweiLiansuyin in the treatment of Hp gastritis with spleen deficiency and dampness-heat syndrome,and to provide clinical application basis for SiJunZi decoction combined with JiaweiLiansuyin in the treatment of Hp gastritis with spleen deficiency and dampness-heat syndrome.Methods:A total of 70 patients with HP-related gastritis diagnosed in the outpatient department of spleen and stomach disease of Jiangsu Hospital of Traditional Chinese Medicine from October 2018 to March 2021 were randomly divided into the treatment group(35 cases)and the control group(35 cases).In the treatment group,4 cases fell out and 31 cases were completed.In the control group,5 cases fell off,and 30 cases were completed.Control to quadruple scheme oral:ai oprah azole enteric-coated metformin hydrochloride(5 mg bid),bismuth potassium citrate capsules(0.22 g bid),amoxicillin capsule(1 g bid),clarithromycin Zyban bid(0.5 g),the treatment group on the basis of the four-league plan add even SiJunZi decoction and flavored drink oral,method of use:daily 1 agent,200 ml each time,2 hours after a meal in the morning and evening.After 2 weeks of treatment,the drug was stopped for 1 month in both groups.Patients were ordered to go to the hospital for reexamination of C13 breath test and follow-up.The sex ratio,age distribution,TCM syndrome efficacy,quality of life score,eradication rate and safety before and after treatment were compared between the two groups.Results:(1)There was no significant gender difference between the two groups(P>0.05);(2)There was no significant difference in age distribution between the two groups(P>0.05).There was no significant difference in the mean age between the two groups(P>0.05).(3)The effective rate of syndrome efficacy in the treatment group was close to that in the control group,both of which were 96.7%.The significant efficiency of syndrome efficacy in the treatment group(80.6%)and the significant efficiency of syndrome efficacy in the control group(46.7%)were statistically significant(P<0.05).(4)Before treatment,there was no significant difference in TCM main symptom scores between the two groups(P>0.05),so it was not comparable.Comparison of intra-group after treatment and before treatment:treatment group and control group was statistically significant(P<0.01);Comparison between groups;The scores of TCM major symptoms in the treatment group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).(5)Before treatment,there was no significant difference in scores of TCM secondary symptoms between the two groups,with no statistical difference(P>0.05),which was not comparable.Comparison of intra-group after treatment and before treatment:treatment group and control group was statistically significant(P<0.01);Comparison between groups:The scores of TCM minor symptoms in the treatment group were significantly lower than those in the control group,and the difference was not statistically significant(P>0.05).(6)Before treatment,there was no significant difference in quality of life scores between the two groups(P>0.05),which was not comparable.Comparison of intra-group after treatment and before treatment:treatment group and control group was statistically significant(P<0.01));Comparison between groups:QOS in the treatment group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).(7)Before treatment,Hp in both groups was positive.After treatment,the eradication rate of Hp in the treatment group was significantly higher than that in the control group,and was statistical significance(P<0.05).(8)A total of 4 patients in the treatment group showed adverse reactions,including vomiting,diarrhea,1 case,and tolerance in 2 cases,while 4 patients in the control group showed adverse reactions,including constipation,diarrhea,dizziness,and tolerance in 1 case.The above patients showed mild drug effects,but refused to adjust their medication and return to the hospital,so they were set as the standard of shedding.Conclusion:SiJunZi Decoction combined with JiaWeiLianSuYin combined with the four-combination scheme in the treatment of HP gastritis syndrome of spleen deficiency and dampness-heat has obvious advantages in improving clinical efficacy,reducing symptom severity and eradication rate,etc.,with high safety,which is worthy of further study and promotion in clinical practice.