| Purpose:Using Kendall’s coefficient of concordance(KCC-)and Coherence(Cohe-)regional homogeneity(Re Ho)to explore the alterations of brain local functional connectivity in acute and remitting relapsing-remitting multiple sclerosis(RRMS),and its clinical relevance.Methods:18 acute RRMS,26 remitting RRMS and 20 healthy controls received resting-state functional magnetic resonance imaging scanning.After data preprocessing and Re Ho(KCC-Re Ho and Cohe-Re Ho)calculation,ANOVA and followed post hoc analysis was used to compare the KCC-Re Ho or Cohe Re Ho maps across groups.Then,partial correlation was utilized to the relationship between KCC-Re Ho or Cohe-Re Ho in the group-different brains regions with statistically significant differences and EDSS、PASAT-3s、MFIS-5 and disease duration.Results:(1)After ANOVA analysis,regions with significant among-group differences detected by the two Re Ho analysis were similar,these regions located in the left superior frontal gyrus(SFG),right SFG,left cuneus and right middle occipital gyrus(MOG)(P <.01,Gaussian random field theory correction).(2)Followed post hoc tests showed that,(i)compared with healthy controls(HC),acute and remitting RRMS both demonstrated decreased KCC-Re Ho(K=7,19,27)or Cohe-Re Ho in the right SFG,left SFG;decreased KCC-Re Ho(K=7,19)in the left medial frontal gyrus(Me FG)and decreased Cohe-Re Ho in the right Me FG(P<0.001).(ii)compared with HC,increased KCC-Re Ho(K=7,19,27)or Cohe-Re Ho in left Cuneus and right MOG only detected in acute RRMS not in remitting RRMS(P<0.001).(iii)compared with HC or remitting RRMS,acute RRMS showed increased KCC-Re Ho or Cohe-Re Ho in the right MOG(P<0.001).(3)Correlation analysis showed disease duration was negatively correlated with the KCC-Re Ho(when K=7,19)of left SFG(r=-0.618,P=0.011;r=-0.633,P =0.008)and left Me FG(r=-0.593,P=0.015;r=-0.501,P=0.048);the KCC-Re Ho(when K=27)of left and right SFG(r=-0.629,P=0.009;r=-0.510,P=0.044)in acute RRMS.Meanwhile,the KCC-Re Ho(when K=7,19)of right SFG(r=-0.574,P=0.020;r=-0.588,P=0.017)was negatively related to EDSS scores in the acute RRMS.In addition,the KCC-Re Ho(when K=7,19)of left SFG(r =-0.590,P =.013;r =-0.599,P =.010)was negatively related to MFIS-5 scores in the remitting RRMS.Conclusion:Both acute and remitting RRMS patients has disease-related brain dysfunction,interestingly,relative to remitting RRMS,the acute RRMS patients mobilized more brain regions involving visual information processing in an attempt to maintain functional stability.In addition,our results also provide a methodological consideration for future Re Ho analysis. |
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