Clinical Study On Carotid Stiffness Measured By Ultrafast Imaging Technology In Patients With Hyperuricemia

Objectives:To evaluate the value of ultrafast pulse wave velocity for carotid stiffness assessment in patients with hyperuricemia.Methods:The present study included 50 patients with hyperuricemia(HUA group)and 42 healthy adults as the control group.Pulse wave velocity-beginning of systole(PWVBS),pulse wave velocity-end of systole(PWVES),the echo parameters of carotid artery,such as PSV,EDV,PI,RI,were measured.Beside,general clinical data of all subjects were collected,including sex,age,history of smoking,blood pressure,heart rate,body mass index(BMI),uric acid,creatinine,fasting plasma glucose,triglycerides(TG),total cholesterol(TC),high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),urea.According to whether the blood lipid was abnormal,HUA group was divided into normal blood lipid group and hyperlipidemia group;According to whether the body mass index(BMI)was normal,HUA group was divided into normal weight group,overweight group.The differences of PWV were assessed in all the groups.Correlation analysis between PWVBS and PWVES of HUA group and traditional cardiovascular disease risk factors was carried out.Results:1.Compared with the control group,PWVBS and PWVES showed a significant increase in the HUA group(p<0.05).2.PWVBS and PWVES in hyperlipidemia group were higher than that in normal blood lipid group(p <0.05);PWVBS in overweight group were higher than that in normal weight group(p<0.05);Compared with normal weight group,there was no significant difference in PWVES of the overweight group(p>0.05).3.PWVBS in HUA group was positively correlated with BMI,uric acid,LDL-C and was negatively correlated with HDL-C(p<0.05).PWVES in HUA group was positively correlated with uric acid,and LDL-C(p<0.05).Conclusions:The UFPWV is a novel modality for the early diagnosis and quantitative assessment of arterial stiffness associated with hyperuricemia.