| Objective To understand the current status of bone mineral density in male patients with type 2 diabetes mellitus,explore the influence of lifestyle and Some biochemical indicators associated with diabetes on bone mineral density level,and analyze the risk factors of abnormal bone mass in type 2 diabetes patients,so as to provide certain reference basis and suggestions for the prevention and treatment of diabetic osteoporosis.Methods A cross-section study was conducted on male type 2 diabetes patients hospitalized in the Department of Endocrinology of Shenzhen Hospital of Peking University from December 1,2018 to December 31,2019.Through a questionnaire,we established information collection table,recorded basic information,lifestyle,Some biochemical indicators associated with diabetes,etc.,and used double X linear bone mineral density meter to measure the bone mineral density of lumbar,femur and femur neck.The survey divided the measurement results into normal bone volume group(A),bone reduction group(B)and osteoporosis group(C),Abnormal bone volume may include abnormal bone volume and osteoporosis.The effects of intergroup lifestyle and diabetes-related factors on bone mineral density levels were compared respectively by using single-factor analysis and Logistic regression analysis.Results A total of 382 patients met the inclusion and exclusion criteria,including 213cases(55.76%)in Group A,152 cases(39.79%)in Group B,and 17 cases(4.45%)in Group C.The general condition of the subjects was analyzed,and the differences in age,BMI,height and weight among the groups with different bone mass were statistically significant(P < 0.05).There was no significant difference in the duration of diabetes among different bone mass groups(P > 0.05).The BMD and the distribution of osteoporosis in different parts of different age groups were studied.The results indicated that the BMD and T values of lumbar spine,femur and femoral neck had statistical significance in different age groups(P < 0.05).Univariate analysis was conducted for age,height,weight,BMI and duration of diabetes mellitus.Results showed that the prevalence of abnormal bone mass in male T2 DM patients was related to age,height,weight and BMI(P < 0.05).With the increase of age,the prevalence of abnormal bone mass increased gradually(P < 0.05).The prevalence of abnormal bone mass increased with the decrease of height,weight and BMI(P < 0.05).The relationship between the course of diabetes mellitus and bone mineral density was analyzed.The results indicated that the prevalence of abnormal bone mass in male T2 DM patients was not related to the course of diabetes mellitus(P > 0.05).Univariate analysis of the lifestyle of the patients indicated that the prevalence of abnormal bone mass in male T2 DM patients was related to smoking/drinking(P < 0.05),and the prevalence of abnormal bone mass in smoking/drinking group was significantly higher than that in non-smoking/drinking group(P < 0.05).Univariate analysis of glucose metabolism indexes in patients showed that there were no significant differences in fasting blood glucose,2-hour plasmablood glucose,fasting C-peptide,2-hour plasma C-peptide and A1 c among different bone mass groups(P > 0.05).Univariate analysis of other components of metabolic syndrome showed that diastolic blood pressure and High-density Lipoprotein Cholesterol were significantly different among different bone mass groups(P < 0.05).Univariate analysis of biochemical indexes of bone metabolism showed that PINP and N-MID were significantly different among different bone mass groups(P < 0.05).Multivariate analysis showed that smoking,long course of diabetes and advanced age were the risk factors for abnormal bone mass in male T2 DM patients(OR=16.254,95%CI: 8.500～1.082,P < 0.05;OR=1.057,95%CI:1.013～1.103,P < 0.05;OR=1.043,95%CI: 1.018～1.068,P < 0.05);Large BMI was a protective factor for abnormal bone mass in men with type 2 diabetes(OR=0.842,95%CI: 0.773～0.917,P<0.05).ROC analysis of age,course of diabetes and BMI in predicting abnormal bone mass indicated that age,course of diabetes and BMI had low diagnostic value in general.Conclusion(1)The prevalence of osteopenia in male patients with type 2 diabetes was 39.79% and osteoporosis was 4.45%;(2)Lifestyle has an influence on bone mass abnormality,among which smoking/drinking is harmful to bone mass;(3)Smoking,advanced age,long duration of diabetes and low BMI are the risk factors for abnormal bone mass in male type 2 diabetes. |
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