Study On The Relationship Between Different Levels Of Bone Mineral Density With Sex Hormone And Insulin Resistance In Male Patients With Type 2 Diabetes Mellitu

Objective To investigate the relationship between different bone mineral density（BMD） with sex hormone and insulin resistance in male patients with type 2 diabetes,so as to deepen the study of BMD in type 2 diabetes.It is of great significance to prevent and treat diabetic osteoporosis.Methods A total of 90 male patients diagnosed with T2DM were enrolled,aged≥50 years.Dual-energy X-ray absorptiometry（DXA）was used to monitor lumbar spine（L1-4）and bilateral femoral neck（FN）bone mineral density（BMD）,based on osteoporosis diagnostic criteria divided all selected subjects into 3 groups:group D1（normal bone mass,30 cases）,group D2（decreased bone mass,30 cases）,group D3（osteoporosis,30 cases）.Each group of patients was tested for glucose and lipid metabolism indicators and sex hormone levels,and the insulin resistance index was calculated.Data were analyzed using SPSS 22.0statistical software.P<0.05 was considered statistically significant.Results There were significant differences in BMI,25-（OH）D₃,serum creatinine（Cr）,testosterone,estradiol and progesterone levels among different bone mineral density groups（P<0.05）.The results of correlation analysis showed that BMD of lumbar spine L1-L4 was positively correlated with BMI,25-（OH）D ₃,testosterone,estradiol and progesterone levels,and negatively correlated with creatinine level.There was a significant positive correlation between BMD of bilateral femoral neck and BMI.The results of Logistic regression analysis showed that estradiol and progesterone were protective factors to inhibit type 2 diabetes mellitus complicated with osteoporosis（P<0.05）.Conclusion Estradiol and progesterone levels are closely related to BMD in male patients with type 2 diabetes,suggesting that estrogen levels also play an important role in male patients with type 2 diabetes and can be used as indicators for early diabetic patients.