Therapeutic Effect Of Water-soluble Contrast Agents In Adhesive Small Bowel Obstruction:a Meta-analysis

Objective:To systematically evaluate the therapeutic effects of water-soluble contrast agents in adhesive small bowel obstruction,and provide evidence-based reference for clinical medication.Methods:Retrieved from Cochrane Library,Pub Med,Embase,CNKI,Wanfang database during inception to September of 2020,RCTs about water-soluble contrast media in the treatment of adhesive small bowel obstruction were collected.After literature screening,data extraction and quality evaluation,Meta-analysis was conducted by using Rev Man5.3 and stata16.Results:A total of 15 items of RCT were included,with a total of 1429 patients.Meta-analysis results showed that The use of water-soluble contrast agents reduces the need for surgery [OR=0.64,95%CI(0.50,0.81),P<0.01];it is beneficial to reduce the remission time of non-surgical patients [MD =-23.37 hours,95% CI(-32.17,-14.57),P=0.002];and the length of hospital stay of non-surgical patients [MD=-2.21 days,95%CI(-2.52,-1.90),P<0.000 01];it can reduce hospital stay [MD =-2.43 days,95% CI(-3.93,-0.92),P=0.002];it will not increase the incidence of complications [OR=1.15,95%CI(0.63,2.10),P=0.65];it cannot reduce mortality [OR=1.26,95%CI(0.94,3.24),P=0.63];it does not help reduce the probability of bowel resection [OR=0.93,95%CI(0.57,1.52),P=0.78].Conclusion:The use of water-soluble contrast media for patients with adhesive small bowel obstruction is safe and effective,reduces the patient’s surgical requirements,and is beneficial to reduce the length of hospital stay and the time for symptom relief.