Analysis Of Risk Factors Of Esophageal Variceal Bleeding In 355 Patients With Liver Cirrhosis In Western Guangxi

Objective: To investigate the risk factors of esophageal variceal bleeding in patients with liver cirrhosis in Western Guangxi.Methods:: A total of 849 patients with liver cirrhosis and esophageal varices diagnosed in Youjiang Medical College for Nationalities from September 2016 to September 2020 were selected.355 patients met the requirements after screening.The clinical data of 355 patients with liver cirrhosis and esophageal varices from September 2016 to September 2020 were retrospectively analyzed,and the general situation of bleeding group and non bleeding group was statistically analyzed.Including gender,age,nationality,whether drinking;whether concurrent symptoms:ascites,hepatic encephalopathy;whether combined with diabetes;etiology(viral,alcoholic,autoimmune,mixed,cryptogenic);laboratory test indicators: alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil)Results: non laboratory examination results: the degree of esophageal varices,portal vein embolism;other: child Pugh grade.The risk factors of rupture and bleeding were analyzed.Results :(1)In general,there was no significant difference in gender,age,nationality,drinking or not between the two groups(P > 0.01);(2)There was no significant difference in ascites between bleeding group and non bleeding group(P >0.01).(3)There was no significant difference in hepatic encephalopathy between bleeding group and non bleeding group(P > 0.01);(4)There was no significant difference in diabetes mellitus between bleeding group and non bleeding group(P >0.01);(5)There was no significant difference between bleeding group and non bleeding group(P > 0.01);there was no significant difference in etiology between bleeding group and non bleeding group(P > 0.01);(6)There was no significant difference in ALT,AST,TBil between bleeding group and non bleeding group in laboratory examination(P > 0.01);ALB and PLT in bleeding group were lower than those in non bleeding group(P < 0.01);PT in bleeding group was longer than that in non bleeding group,The difference was statistically significant(P < 0.01);(7)The degree of varicose veins in the bleeding group was significantly different from that in the non bleeding group(P < 0.01);but there was no significant difference in whether the bleeding group and the non bleeding group were complicated with portal vein embolism(P < 0.01);(8)The child Pugh grade in the bleeding group was significantly different from that in the non bleeding group(P < 0.01);(9)Binary logistic regression analysis showed that ALB(OR = 0.823,P < 0.01)and PLT(OR =0.988,P < 0.01)were protective factors of esophageal variceal bleeding;PT(OR =1.546,P < 0.01),degree of esophageal varices(OR = 4.906,P < 0.01)and child Pugh grade(OR = 1.807,P < 0.01)were independent risk factors.Conclusion: ALB and PLT are the protective factors of esophageal variceal bleeding.PT,degree of esophageal varices and child-Pugh classification are the independent risk factors of esophageal variceal bleeding.The above indicators can be used as a reference for predicting esophageal variceal bleeding.