Study On Serum Level Of G Protein Coupled Bile Acid Receptor 1 In Patients With Acute Pancreatitis

Objective: To study the serum levels of G protein-coupled bile acid receptor 1(GPBAR1)in patients with acute pancreatitis and to explore the correlation between the level of GPBAR1 and the severity of acute pancreatitis,so as to provide a new idea for early assessment of the severity of acute pancreatitis.Methods: Fifty-six patients with acute pancreatitis in the Department of digestive Medicine of Hebei General Hospital from March 2019 to January2021 were selected as the study subjects and a total of twenty-eight healthy subjects were selected as the control group.Basic data and laboratory test on admission were collected.The fasting serum of acute pancreatitis patients on admission and the control group were collected.The serum GPBAR1 concentration was detected by enzyme linked immunosorbent assay and the severity of pancreatitis was assessed.Evaluating the severity of acute pancreatitis,whether there was complicated by systemic inflammatory response syndrome(SIRS)and pleural effusion,observing the change of GPBAR1 levels in acute pancreatitis,explore the relationship between serum GPBAR1 levels and the severity of acute pancreatitis.Results:1.The serum levels of GPBAR1 in acute pancreatitis group was lower than that in healthy control group(P<0.05).2.In acute pancreatitis patients,the serum levels of GPBAR1 were inversely correlated with C-reactive protein(CRP)(P<0.05),and had no correlation with white blood cell count(WBC),neutrophil lymphocyte ratio(NLR),neutrophil ratio,total cholesterol(TC),triglyceride(TG),blood,amylase,calcium ion,procalcitonin(PCT),albumin(ALB)(P>0.05).3.The serum levels of GPBAR1 severe acute pancreatitis(SAP)was significantly lower than that in mild acute pancreatitis(MAP)(P<0.05).SAP serum GPBAR1 levels was lower than that of moderate severe acute pancreatitis(MSAP)and MSAP serum GPBAR1 levels was lower than that of MAP,but the difference was not statistically significant(P>0.05).4.The serum levels of GPBAR1 in SIRS group was lower than that in without SIRS(P<0.05).5.The serum levels of GPBAR1 in acute pancreatitis with pleural effusion were lower than that in acute pancreatitis without pleural effusion(P<0.05).Conclusions:1.The levels of GPBAR1 in serum was lower in acute pancreatitis.2.In acute pancreatitis patients,the levels of serum GPBAR1 were inversely correlated with CRP.3.The serum level of GPBAR1 is an early indicator of the severity of acute pancreatitis and is lower in severe cases,complicated with SIRS and complicated with pleural effusion.