Influence Of Body Mass Index On Prognosis Of Elderly Patients With Chronic Obstructive Pulmonary Disease

Objective: Objective to investigate the differences of lung function,blood gas ion analysis,immune function and quality of life in elderly COPD patients with normal weight,overweight and obesity,and to evaluate the impact of BMI on the prognosis of COPD.Methods: 125 patients with acute exacerbation of COPD in our hospital from September2018 to August 2019 were collected,including 84 males and 41 females,aged 60-87 years.According to the Chinese adult BMI classification recommended by wgoc,the patients were divided into three groups: normal weight group(BMI 18.5-23.9 kg / m2),overweight group(BMI 24-27.9 kg / m2)and obesity group(BMI ≥ 28 kg / m2).PO2,p CO2,FEV1 / FVC,CD4 + T cells and CD8 + T cells were collected.SF-36 scale was used to evaluate the quality of life of all patients.Multivariate analysis of variance and pairwise comparison were used for comparison between groups.Pearson correlation analysis was used to evaluate the relationship between BMI and prognostic factors in elderly patients with COPD.The effect of BMI on oxygen partial pressure was analyzed by univariate linear regression.Result: Among 125 elderly COPD patients,50 were normal weight group,50 were overweight group,and 25 were obese group.Compared with the three groups,PO2,FEV1 / FVC,CD4 + T cells,physiological function,general health,social function and mental health were significantly different.There was no significant difference in PCO2,CD8 + T cells,physiological function,physical pain,energy and emotional function among the three groups.The correlation analysis between BMI and all prognostic factors of COPD showed that PO2,physiological function,general health status and social function were significantly correlated with BMI.Furthermore,the univariate linear regression analysis between BMI and PO2,physiological function,general health status and social function showed that BMI was negatively correlated with PO2,and the fitting degree of the other three factors was very low.Conclusion: The prognosis of elderly COPD patients with normal weight and overweight is better than that of obese patients.Weight loss is expected to improve the prognosis of COPD patients to a certain extent.