| Objectives To explore the effect of Zhenlian Mingmu Capsule(ZMC)on nonproliferative diabetic retinopathy(NPDR),which is liver and kidney yin deficiency,phlegm dampness and blood stasis,so as to provide a new treatment scheme for NPDR.Methods 1 108 patients with NPDR were randomly divided into trial group and control group;2 In the routine control of blood sugar at the same time,Cases in the control group was treated with calcium dobesilate capsules;cases in the trail group was treated with ZMC.The course of treatment was 12 weeks for the both groups;3 The degree of retinal microangiopathy(such as the number of retinal microangioma,retinal microvascular hemorrhage,retinal microvascular exudation),visual acuity TCM syndrome score,Cystatin C(Cys C),fasting blood glucose,glycosylated hemoglobin,blood lipid and other indexes were observed and recorded before and after treatment.Statistics methods were used for data analysis.Results 1 There was no significant difference in age,gender,course of disease,NPDR degree and stage composition between the two groups(P > 0.05).2 Comparison of TCM syndrome efficacy: after treatment,the TCM syndrome scores of the two groups were lower than those before treatment(P < 0.05),and the total effective rate of the trail group(88.0%)was higher than that of the control group(65.3%),the difference was statistically significant(P < 0.05).3 Fundus changes: after treatment,the number of microangioma,bleeding point and exudation of retinopathy in the two groups were decreased,and therapeutic effects of the trail group was stronger than that of the control group(P < 0.05);the reduction rate of retinopathy degree in the trail group was higher than that in the control group(76.0% > 61.2%),and the aggravation rate of retinopathy degree in the trail group was lower than that in the control group(6.0% < 14.3%),P < 0.05.4 Visual acuity:after treatment,the visual acuity of cases in the two groups were improved,and the improvement degree of the trail group was higher than that of the control group(P <0.05);The total effective rate of visual acuity in the trail group(84.0%)was higher than that in the control group(67.3%),and the difference was statistically significant(P < 0.05).5 Cystatin C: the levels of Cys C from cases in the two groups post treatment were lower than those pre-treatment,and the reduction degree in the trail group was significantly higher than that in the control group(P < 0.05).6 Fasting blood glucose,glycosylated hemoglobin,blood lipid: Fasting blood glucose of the two groups decreased after treatment,and the trail group decreased more significantly,the difference was statistically significant(P < 0.05),glycosylated hemoglobin,TC,TG,LDL-C,HDL-C indexes had no significant change before and after treatment,the difference was not statistically significant(P > 0.05).7 There was no significant difference in liver function and renal function between the two groups,pre-and post-treatment(P > 0.05).Indexes fluctuated in the normal range,which indicated that there was no obvious adverse reaction on cases in the two groups,and the safety was reliable.Conclusion 1 ZMC combined with calcium dobesilate capsule is superior to calcium dobesilate capsule in improving the TCM syndrome,fundus diseases(retinal microangiopathy,microangioma,bleeding point,exudation number),visual acuity Cys C and FPG of patients with NPDR.2 ZMC combined with calcium dobesilate capsule can effectively improve the clinical symptoms and quality of life quality of patients,which is worthy of further promotion in clinical practice.Figure0;Table12;Reference 103... |
PDF Full Text Request