Effect Of Short-term Treatment With Insulin Degu Versus Insulin Glargine On Blood Glucose Fluctuation In Patients With Type 2 Diabetes Mellitus

Objectives By comparing the glycemic control effect,the degree of blood glucose fluctuation and the risk of hypoglycemia between degu insulin and glargine insulin,and to explore the advantages of the new long-acting degu insulin in lowering blood glucose,to provide a clinical basis for a smoother and more efficient glycemic control.Methods To collect clinical data of patients with T2 DM who were hospitalized in the endocrinology department of Hebei General Hospital from June 2020 to December2020,including general information,fasting blood glucose,fasting insulin,fasting Cpeptide,2-hour postprandial blood glucose,glycated hemoglobin,lipids and other blood indicators.All patients were given insulin pump treatment for 7 days after admission(introductory period)and then discontinued the insulin pump and switched to different types of long-acting insulin(degu or glargine insulin),of which 31 cases were in the degu group and 30 cases in the glargine group.We compared the glycemic control effect,the degree of blood glucose fluctuation and,the risk of hypoglycemia of the two long-acting insulins.SPSS25.0 software was applied for statistical analysis.Results 1 There are no statistical differences between the two groups in terms of gender and age matching before treatment,history of smoking and the duration of diabetes,drinking,history of hypertension,systolic blood pressure,diastolic blood pressure,fasting blood glucose,fasting insulin,fasting C-peptide,2-hour post-blood glucose,Hemoglobin alc,lipids,and other related indexes are not statistically different(P>0.05);2 Fasting blood glucose and 2-hour post-blood glucose decreased after treatment with both longacting insulins compared with those before treatment(at admission and after insulin pump treatment),and the decrease is relatively more pronounced in degu,and the difference is statistically significant(P<0.05);3 There are no significant differences between the two groups of patients in the mean blood glucose(MBG),the standard deviation of blood glucose(SDBG),the mean amplitude of glycemic excursions(MAGE)and the TIR after glargine insulin treatment is higher than that of the glargine insulin group,and the difference is statistically different(P<0.05);there was no statistical difference compared with the largest amplitude of glycemic excursions(LAGE),the mean of daily difference(MODD),the incidence of hypoglycemia between the two groups.Conclusions For patients with type 2 diabetes who are hospitalized after the initial intensive insulin pump treatment,switching to degu insulin or glargine insulin to continue treatment,compared to the degu insulin group,the glucose lowering effect is more obvious,blood glucose fluctuation is less,TIR attainment rate is higher without increasing the risk of hypoglycemia,degu insulin is a more effective and safe long-acting insulin.Figure0;Table9;Reference 145...