| Purpose:Sema4D(Sema4D)is a family member of transmembrane and secretory proteins.During the process of platelet activation,it splits and falls off,enters the blood circulation,and becomes serum soluble Sema4 D.Related studies have shown that serum soluble Sema4 D is closely related to inflammation,platelet activation andatherosclerosis.Diabetic nephropathy is one of the microvascular complications of type 2 diabetes mellitus.It is an important cause of end-stage nephropathy.Its occurrence and development are related to endothelial cell damage and platelet activation.At present,the treatment is limited and the prognosis is poor.At present,urinary microalbumin creatinine ratio(ACR)is often selected as the clinical indicator of diabetic nephropathy stage.The purpose of this study is to explore the relationship between serum soluble Sema4D(s Sema4D)level and urinary microalbumin creatinine ratio(ACR)in patients with type 2 diabetes mellitus,so as to provide a new predictive index for microvascular complications in patients with type 2diabetes mellitus and guide the treatment of diabetic nephropathy.Methods:We included 135 type 2 diabetes patients in our study.24-hour urine samples were collected to detect the urinary microalbumin creatinine ratio(ACR).Type 2 diabetes patients with ACR ≤30mg / g were included in the " diabetic group"(n = 61),and type 2diabetes patients with ACR > 30 mg / g were included in the "proteinuria group"(n = 74).The general situation and clinical biochemical indexes of the patients were recorded.The serum level of s Sema4 D was detected by ELISA.Results:1.The concentration of s Sema4 D in the proteinuriay group(3.71 ± 0.18)ug/ L was significantly higher than that in the diabetic group(3.45 ± 0.30)ug / L(P <0.001).2.Among all the researchers,Sperman correlation analysis showed that the level of s Sema4 D was positively correlated with age(P = 0.008)and urinary microalbumin creatinine ratio(P = 0.000),however,s Sema4 D was negtaively correlated with e-GFR(P =0.000)and HDL(P = 0.000).3.Among all the patients included in the study,whether or not with proteinuria(0 for no proteinuria,1 for with proteinuria)was taken as the dependent variable,and the results of logistic regression analysis showed that s Sema4D(or = 1.95 P = 0.000)is an independent risk factor affecting the occurrence of diabetic nephropathy.Conclusions:1.Patients with type 2 diabetes mellitus and proteinuria have higher serum level of s Sema4 D than those without proteinuria.2.In patients with type 2 diabetes mellitus,the concentration of s Sema4 D was positively correlated with age and urinary microalbumin creatinine ratio.3.s Sema4 D is an independent risk factor of type 2 diabetic nephropathy,which may play a synergistic role in the development of diabetic nephropathy. |
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