| Objective: Using the prescriptions formulated based on the principle of "warming the middle and lowering adverse effects" Huangqi Jianzhong Decoction combined with proton pump inhibitors for the treatment of gastroesophageal reflux cough due to deficiency of qi and inversion,to explore the clinical effect of traditional Chinese medicine in treating gastroesophageal reflux cough significance.Methods: Sixty patients who met the inclusion criteria were randomly divided into a control group and a treatment group.Both groups were given general treatment.The control group was given lansoprazole enteric-coated tablets on the basis of general treatment;the treatment group was given lansoprazole enteric-coated tablets on the basis of the control group A traditional Chinese medicine plus Astragalus Jianzhong Decoction based on the principle of the method of temperature reduction and deregulation.Observe and record the TCM clinical symptom score,TCM clinical symptom score,TCM syndrome curative effect,cough psychological score,and recurrence rate after 3 months of drug withdrawal for the two groups of patients after2 weeks and 8 weeks of treatment,and finally make statistics Analyze and draw conclusions.Results:(1)The baseline data of the two groups of patients were not significantly different at the time of enrollment,and they were comparable.(2)Comparison of clinical symptom scores of main symptoms: intra-group comparison:after 2 weeks and 8 weeks after treatment,the two groups can improve the clinical symptom scores of the main symptoms of the patients,and the difference is statistically significant(P<0.05);between groups Comparison: After 2 weeks of treatment,the control group was better than the treatment group in improving acid reflux or panemetic water score,belching or reflux score(P<0.05),and the two were more effective in improving day cough score and night cough score It was equal,the difference was not statistically significant(P>0.05).After 8 weeks of treatment,the treatment group was better than the control group in improving acid regurgitation or vomiting water score,belching or reflux score,day cough score,and night cough score,and the difference was statistically significant(P<0.05).(3)Comparison of clinical symptom scores of secondary symptoms: intra-group comparison: After 2weeks of treatment,the two groups can improve the clinical symptom scores of each symptom.The difference between the treatment group and the control group was not statistically significant(P>0.05);After 8 weeks of treatment,the two groups can improve the clinical symptom scores of each symptom,and the differences are statistically significant(P<0.05).Comparison between groups: After 2 weeks and 8weeks of treatment,the difference in clinical scores for each symptom between the two groups was statistically significant(P<0.05).It shows that the improvement in the scores of secondary symptoms in the treatment group and the onset time are significantly better than those in the control group.(4)Comparison of the total score of clinical symptoms: Comparison within the group: after 2 weeks and 8 weeks of treatment,the two groups can improve the total score of clinical symptoms,the difference is statistically significant(P<0.05).Comparison between groups: After 2weeks and 8 weeks of treatment,the difference in the total score of clinical symptoms between the two groups was statistically significant(P<0.05).(5)Comparison of the efficacy of clinical syndromes between the two groups: After 8 weeks of treatment,the treatment group was better than the control group in terms of the efficacy and total effective rate of TCM syndromes.(6)Comparison of cough psychological score:comparison within the group: after 2 weeks of treatment,the two groups can improve the cough psychological score,the difference between the control group is not statistically significant(P>0.05),the difference between the treatment group is statistically significant(P<0.05)After 8 weeks of treatment,both groups could improve the psychological score of cough,and the difference was statistically significant(P<0.05).Comparison between groups: After 2 weeks of treatment,both groups can improve the psychological score of cough,the difference between the treatment group is statistically significant(P<0.05),and the difference between the control group is not statistically significant(P>0.05);after 8 weeks of treatment,Both groups can improve the psychological score of cough,and the difference is statistically significant(P<0.05).It shows that both the treatment group and the control group can improve the cough psychological score,but the improvement of the cough psychological score and the improvement time of the treatment group are better than the control group.(7)Comparison of recurrence rate: 3 months after the end of treatment,after statistical analysis,the recurrence rate of the treatment group was significantly lower than that of the control group.Conclusion:(1)The prescriptions formulated based on the principle of Wenzhong Jiangni decoction combined with Huangqi Jianzhong Decoction combined with proton pump inhibitors are significantly better than the improvement in clinical symptoms and cough psychological scores of patients with gastroesophageal reflux cough(deficiency and qi adversity)Control group.(2)Compared with the control group,the prescription plus Huangqi Jianzhong Decoction combined with the proton pump inhibitor formulated on the principle of the method of warming and reducing the inverse,can reduce the recurrence rate within a certain period of time,and has a certain long-term effect.(3)The traditional Chinese medicine plus Huangqi Jianzhong Decoction combined with proton pump inhibitors based on the principle of the method of warming the middle and reducing the inverse is safe and effective in the treatment of gastroesophageal reflux cough(deficiency and qi adversity syndrome).It has certain clinical application value and is worth further study. |
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