The Study On The Secondary Metabolites From Ganoderma Sp.and Their α-glucosidase Inhibitoty Activities

Ganoderma,belongs to the family Ganoderma of Ganodermataceae,is renowned for its health-promoting and tonic properties,and has been a traditional Chinese medicine for more than 2000 years.Most of the pharmacological effects have been reported on Ganoderma,such as:immune regulation,anti-tumor,anti-diabetic.To the good traditionally medicinal value and biological pharmacological activity,Ganoderma attracts attention in new drug research.This paper was divided into three parts.First part:review on the chemical constituents and pharmacological research of Ganoderma sp..Second part:study of Ganoderma sp.secondary metabolites.In virtue of chromatography separation（silica gel,RP-18,MCI）and extensive spectroscopic analysis（NMR,2D-NMR,MS,IR,UV,optical rotation）,eight compounds were purified and determined,including four novel lanostane triterpenoids（2,3,5,6）.Last part:research on?-glucosidase inhibitory activities.In these compounds,1-6 and 8 showed potent?-glucosidase inhibitory activities in vitro.Especially compounds 3 and6,with IC₅₀of 0.04 m M and 0.01 m M,which were 40 and 160 times lower than acarbose（1.63 m M）respectively,suggesting that they could be new chemical entities on treatment of diabetes.