| Objective: By observing the clinical syndromes of patients with atherosclerotic cerebral infarction at different time points,we know the distribution of main syndromes in every stage of stroke.So it can further explore the changes in the distribution of symptoms from acute stage to recovery and from recovery to sequela period of atherosclerotic cerebral infarction,and provide a certain train of thought for the treatment of atherosclerotic cerebral infarction in clinical work.Methods: The information of TCM four diagnoses was collected in detail from three nodes within 2 weeks,12 th weeks and 24 th weeks,and the information acquisition form was filled in to the database.Firstly,frequency analysis in SPSS 22.0 was used to analyze the frequency of symptoms in each node,which was more than 10%.Then the symptoms of these three nodes were analyzed by index cluster analysis,and then according to the clustering results and "Diagnostic scale of Ischemic apoplexy syndrome factor" to analyze the distribution of TCM syndromes of these three nodes.In order to explore the evolution of the syndrome in different stages of large atherosclerotic cerebral infarction.By using the probability transfer matrix,and the syndrome evolution rule of patients with atherosclerotic cerebral infarction from acute stage to recovery and from recovery to sequelae period was obtained.Results:The clustering results of four diagnoses of TCM in acute stage of atherosclerotic cerebral infarction can be divided into wind syndrome,phlegm heat syndrome and qi deficiency and blood stasis syndrome.The clustering results in recovery period can be divided into three categories: Phlegm dampness,qi deficiency and blood stasis,phlegm heat;The results of syndromes clustering in sequelae period can be divided into three categories: blood stasis,phlegm dampness and deficiency of qi.It can be concluded that qi deficiency and blood stasis throughout the onset of cerebral infarction.According to the frequency analysis of syndrome factors in different stages of cerebral infarction: Distribution of syndrome in acute stage of large atherosclerotic cerebral infarction: 53.1%(phlegm dampness)> 44.2%(internal wind)> 31%(blood stasis)>24.8%(qi deficiency)and 22.1%(internal fire)> 2.7%(Yin deficiency).Recovery period:58.4%(phlegm dampness)>53.1%(blood Stasis)>31%(qi deficiency)>25.7%(internal fire)> 9.7%(Yin deficiency)> 8.8%(wind syndrome).Sequelae period :58.4%(qi deficiency)>50.4%(blood stasis)26.5%(phlegm dampness)>12.4%(Yin deficiency)>9.7%(internal fire)> 2.7%(internal wind).From the acute to the recovery period,the probability of transfer of wind symptoms is only 5.4 % of the probability of persistence,while the probability of persistence of phlegm dampness and blood stasis is44.6 % and 51.9 %,respectively.The probability of persistence of internal fire,Qi deficiency and Yin deficiency is 28.6 %,37.1 % and 23.3 %,respectively.The probability of the persistence of wind symptoms during the recovery period to the sequelae period is0.5 %,the probability of continuous existence of internal fires is 10.9 %,the probability of continued existence of phlegm and dampness syndrome is 18.5 %,the probability of continuous existence of blood stasis syndrome is 20.3 %,and the probability of continuous existence of gas deficiency is 22.1 %,and the probability of continued existence of Yin deficiency is 12.1 %Conclusion:The pathogenesis of apoplexy is caused by the mutual influence and interaction of many factors,and the pathogenesis of apoplexy is complex and changeable.In the acute stage of apoplexy,wind syndrome is the main symptom,which is the most prominent syndrome during the onset of apoplexy.During the recovery period,the probability of wind syndrome decreased gradually,while phlegm syndrome and fire heat syndrome gradually increased.Sequelae period,qi deficiency and blood stasis syndrome are the main syndromes.Qi deficiency and blood stasis throughout the onset of cerebral infarction.In addition,in the clinical treatment of large atherosclerotic cerebral infarction,we should strengthen the identification of syndromes and the application of related intervene method,and find the inflection point of syndrome change timely,and take appropriate treatment measures.So as to improve the prognosis of the disease. |
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