| Objective:This study intends to investigate the incidence and distribution of cerebral microbleeds(CMBs)in patients with acute large artery atherosclerotic stroke(LAAS),and to explore and analyze the risk factors of CMBs in LAAS patients,so as to prevent the occurrence of CMBs,to provide a basis for reducing the incidence of LAAS patients and bleeding transformation.Methods:A retrospective analysis of LAAS patients who were hospitalized in the Department of Neurology,Xianyang Hospital,Yan’an University from January 2019 to December 2020,and perfected the Susceptibility Weighted Imaging(SWI)examination,and a total of 164 LAAS patients who met the inclusion criteria were collected.According to whether there are CMBs,they are divided into CMBs group and no CMBs group.According to the number,they are divided into no CMBs group,mild(1-4)group,moderate(5-9)group,and severe(≥10)group.The distribution positions are divided into lobe group,deep group,subtentorial group,and mixed group.Record each patient’s age,gender,coronary heart disease history,smoking history,alcohol drinking history,hypertension,diabetes history,past cerebral infarction history,history of antithrombotic drugs,blood lipids,blood sugar,uric acid,creatinine,WMH score and admission to the hospital Time NIHSS score,statistical analysis.Results:1.A total of 164 LAAS patients were enrolled in this study,87 were in the CMBs group,and 77 were in the no CMBs group.The positive detection rate of CMBs was 53.0%.CMBs distribution location: 12 people(13.79%)in the lobe,20 people(22.99%)in the deep part,16 people(18.39%)under the tentacles,39 people(44.83%)in the mixed area;severity of CMBs: There were 77 people in the no CMBs group(46.95%);46 people in the mild group(28.05%),24 people in the moderate group(14.63%),and 17 people in the severe group(10.37%).2.Comparison of data with CMBs group or no CMBs group2.1 CMBs group(87 people): aged between 43-86 years old,with an average age of65.53±10.07;56 males(64.4%),31 females(35.6%);66 hypertensive patients(75.9%);diabetes There were 22 patients(25.3%);12 patients(13.8%)with coronary heart disease,32 patients(36.8%)with a history of cerebral infarction;24 patients(27.6%)with a history of antithrombotic drugs;24(27.6%)smokers and 12 drinkers(13.8%).2.2 No CMBs Group(77 people): aged between 23-86 years old,with an average age of 61.57±10.93 years old,53 males(68.8%),24 females(31.2%);44 people with hypertension(57.1%),15 diabetic patients(19.5%),18 patients with coronary heart disease(23.4%);13 patients(16.9%)with a history of cerebral infarction;12 patients(15.6%)with a history of antithrombotic drugs;19 smokers(24.9%),16 drinkers(20.8%).2.3 Compare the data of the two groups(CMBs group or no CMBs group): the differences in hypertension,history of cerebral infarction,age,LDL-C,and WMH scores of the two groups were statistically significant 0.013<0.05,0.005<0.05,0.013<0.05,0.014<0.05,0.000<0.05).There was no statistical difference in other risk factors.The two groups of statistically significant(P<0.05)factors were used as independent variables,and the presence or absence of CMBs was used as the dependent variable to perform a Logistic multivariate correlation analysis.The results showed that CMBs and age(OR=1.025 95%CI 0.991-1.060),high Blood pressure(OR=2.176 95%CI 1.041-4.546).and WMH score(OR=1.329 95%CI 1.060-1.666)are significantly correlated and are independent risk factors.3.Spearman rank correlation analysis was performed on age and WMH.It was found that in LAAS patients with CMBs,age and CMBs were positively correlated(rs=0.178,P=0.023),and WMH and CMBs were positively correlated(rs=0.435,P= 0.000).Conclusion:1.The prevalence of LAAS with CMBs is higher.2.A history of hypertension,a history of cerebral infarction,and the existence of WMH are independent risk factors for CMBs in LAAS patients.3.Age and WMH severity are positively correlated with the severity of LAAS combined with CMBs. |
PDF Full Text Request