Clinical Study On The Treatment Of Hyperprolactinemia Of Liver Stagnation And Kidney Deficiency By The Method Of Soothing Liver And Tonifying Kidney

Objective:To observe the level of serum prolactin and related clinical symptoms before and after treatment of hyperprolactinemia of liver depression and kidney deficiency by soothing liver and tonifying kidney,and to explore the mechanism of action of traditional Chinese medicine.Methods:40 cases were selected and treated with Chinese herbal medicine of soothing liver and tonifying kidney for 3 months.The changes of serum PRL and symptoms of late menstruation,less menstrual volume,galactorrhea,lumbar and knee acidity,breast swelling and pain were observed before and after treatment.Results:Total curative effect:After treatment,5 cases were cured(12.5%),13 cases were markedly effective(32.5.00%),18 cases were effective(45.00%)and 4 cases were ineffective(10%).Menstrual condition:After treatment,the delayed menstruation and less menstrual volume were significantly improved,and the scores of menstrual cycle and less menstrual volume before and after treatment were significantly different(P<0.05).Breast discharge:After treatment,the symptoms of breast discharge were significantly improved,and the scores of breast discharge before and after treatment were significantly different(P<0.05).Symptoms of TCM:After treatment,TCM symptoms improved significantly.There were significant differences before and after treatment in chest and breast pain,lumbar and knee soreness,dizziness and tinnitus,emotional depression or irritability,abdominal distension,dry throat and mouth,frequent nocturnal urination(P<0.05).Prolactin:After treatment,serum prolactin level was lower than that before treatment,the difference was significant(P<0.05).The PRL of 5 recovered patients was within normal range after 3 months of withdrawal,and no recurrence was found.No adverse events occurred during the treatment,and the safety evaluation was highCONCLUSION:The therapy of soothing liver and tonifying kidney can significantly improve the clinical symptoms of patients with hyperprolactinemia of stagnation of liver and deficiency of kidney,reduce the level of serum prolactin,and is safe with no adverse reactions.It has clinical application value.