Observation On The Therapeutic Effect Of Piweikang Prescription On Hp-Associated Gastritis Of Spleen And Stomach Damp-heat Type In Children

ObjectiveTo observe the clinical effect of Piweikang prescription on Hp-Associated Gastritis of Spleen and Stomach Damp-heat Type in children and to explore its mechanism,and to provide new methods and clinical basis for the treatment of children’s spleen and stomach damp-heat type Hp-Associated gastritis.MethodsThis study was approved by the medical ethics committee of our hospital,and 82 cases of spleen and stomach damp-heat type Hp-Associated gastritis were included in the study according to the diagnostic criteria of Chinese and Western medicine.They were divided into two groups according to the randomization method,41 cases/group.The control group was treated with standard triple therapy,and the treatment group was treated with oral Piweikang prescription.Both groups were treated for 2 weeks,and the follow-up time point was 1 month after drug withdrawal and 4 months after drug withdrawal.The general condition,total effective rate,TCM symptom score,major symptom score,minor symptom score,eradication rate,recurrence rate and adverse reactions of the two groups of children before and after treatment were compared.Results1.General situation comparison:Comparison of gender,age and course of illness between the two groups of children,the difference after analysis is not statistically significant(P>0.05),and there was comparability at.baseline.2.Comparison of clinical efficacy between the two groups of children:The total effective rate of the treatment group was 94.87%,and the total effective rate of the control group was 76.92%.The clinical efficacy of the treatment group was better than that of the control group(P<0.05).3.Comparison of TCM symptom scores before and after treatment in the two groups of children:Comparison between the two groups before treatment showed no statistical difference after analysis(P>0.05),and there was comparability at baseline;Compare the TCM symptom scores of the two groups of children before and after treatment within the group,and the TCM symptom scores of the two groups after treatment are better than before treatment(P<0.01);However,comparing the symptom scores of TCM after treatment between the two groups,the treatment group was better than the control group(P<0.05).4.Comparison of scores of main symptoms before and after treatment in two groups of children:Comparison between the two groups before treatment showed no statistical difference after analysis(P>0.05),and there was comparability at baseline;The main symptom scores of the two groups of children before and after treatment were compared within the group,and the main symptom scores of the two groups after treatment were better than before treatment(P<0.01);However,the main symptom scores of the two groups after treatment were compared between the two groups,and the treatment group was better than the control group(P<0.01).5.Comparison of secondary symptom scores before and after treatment in two groups of children:Comparison between the two groups before treatment showed no statistical difference after analysis(P>0.05),and there was comparability at baseline;The scores of minor symptoms before and after treatment in the two groups were compared within the group.The scores of minor symptoms after treatment in both groups were better than before treatment(P<0.01);However,the minor symptom scores of the two groups after treatment were compared between the two groups,and the treatment group was better than the control group(P<0.05).6.Comparison of eradication rates of children in the two groups after one month of discontinuation:The eradication rate of the treatment group was 82.05%,and the eradication rate of the control group was 66.67%.The difference after analysis was not statistically significant(P>0.05).The eradication effect of the two groups was equal.7.Comparison of relapse rate between two groups of children 4 months after drug withdrawal:The relapse rate in the treatment group was 6.25%,and the relapse rate in the control group was 30.77%.The difference after analysis was not statistically significant(P<0.05).The treatment group was superior to the control group.8.Two groups of adverse reactions:No adverse reactions occurred during the treatment of the two groups of children.ConclusionCompared with standard triple therapy,Piweikang prescription can significantly improve the clinical efficacy of Hp-Associated gastritis of Spleen and Stomach Damp-heat Type in children,significantly improve clinical symptoms,the eradication effect is exact,and the recurrence rate after eradication is lower,which is worthy of clinical reference.