| Objective: To observe and evaluate the clinical effect of Jiawei Lizhong Decoction(clinical experience formula)on the prevention of toxic and side effects of lung cancer after chemotherapy by using the important thought of "prevention before disease" of traditional Chinese medicine,and try to find a more safe and effective comprehensive treatment method of traditional Chinese and Western medicine for the prevention and treatment of toxic and side effects after chemotherapy,so as to improve the quality of life of patients with lung cancer undergoing chemotherapy.Methods:60 patients with lung adenocarcinoma who met the inclusi on criteria were selected from the Department of lung diseases o f Qingdao Haici hospital from December 2017 to December 2019.Th ey were randomly divided into treatment group(n=30)and control group(n=30)according to the principle of random control.Duri ng the chemotherapy,the control group was treated with pemetrex ed combined with nedaplatin.The treatment group was given jiawe ilizhong Decoction on the basis of the control group For treatme nt,both groups were supported by western medicine to protect st omach and stop retching and reduce side effects.Observe and com pare the changes of blood cell(leukocyte,platelet,etc.)count,liver and kidney function,TCM symptoms,physical condition and quality of life of the two groups before and after chemotherapy,And the incidence and severity of gastrointestinal reaction and myelosuppression after chemotherapy were observed and compared.Results:(1)Digestive tract reaction: after 7 days of chemotherapy,the incidence of nausea,vomiting and anorexia in the treatment group was lower than that in the control group,and the severity was lighter than that in the control group(P<0.05),the difference was statistically significant.(2)Myelosuppression: after 8 days of chemotherapy,D1(1 day before chemotherapy)and D8(7 days after chemotherapy)were selected for analysis and comparison.The results showed that there was no significant difference between the two groups before chemotherapy(P>0.05).After chemotherapy,the blood cells(white blood cells,platelets,etc.)in the treatment group were higher than those in the control group The incidence and severity of myelosuppression were significantly lower than that of the control group(P<0.05),the difference was statistically significant.(3)Liver and kidney function: the liver and kidney function tox icity was observed for 22 days before and after chemotherapy.D1(1 day before chemotherapy)and D22(the 21 st day after chemoth erapy)were selected for analysis and comparison.The results sh owed that there was no significant difference in liver function between the two groups before and after chemotherapy(P>0.05).T he incidence and severity of liver function abnormality in the t reatment group after chemotherapy were lower than those in the c ontrol group(P<0.05),the difference was statistically signific ant.There was no significant difference in renal function betwee n the two groups before and after chemotherapy(P>0.05).(4)Symptoms of Yang deficiency in traditional Chinese medicine: the occurrence of clinical symptoms of Yang deficiency before and after chemotherapy was continuously observed for 8 days.One day before chemotherapy(D1)and the seventh day after chemotherapy(D8)were selected for comparison.The results showed that there was no significant difference between the two groups before and after chemotherapy(P>0.05).After chemotherapy,the score of Yang deficiency in the control group was significantly higher than that in the treatment group(P<0.05),the difference was statistically significant.(5)Physical condition: the results showed that there was no sig nificant difference in Karnofsky score(KPS score)between the t wo groups before and after chemotherapy(P>0.05).After chemothe rapy,the scores of the two groups decreased,but the overall sc ore of Karnofsky in the treatment group was higher than that in the control group(P<0.05),the difference was statistically sig nificant.(6)Quality of life: the results showed that there was no signif icant difference between the two groups before and after chemoth erapy(P>0.05).After chemotherapy,the scores of the two groups were lower than before chemotherapy,but the overall evaluation,the quality of life score of the treatment group was higher tha n that of the control group(P<0.05),the difference was statist ically significant.Conclusion: Jiawei Lizhong decoction can effectively reduce the incidence and severity of gastrointestinal reaction,myelosuppre ssion and liver dysfunction caused by chemotherapy,relieve the clinical symptoms of TCM,improve the physical condition of pati ents and improve the quality of life of patients after chemotherapy. |
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