Objective: This study evaluated the efficacy of Jiawei Lizhong Decoction on gastrointestinal side effects after chemotherapy for small cell lung cancer,and studied its related mechanism of action,so as to provide new methods and diagnosis and treatment basis for the treatment of gastrointestinal side effects after chemotherapy for small cell lung cancer.Methods: According to the inclusion criteria and exclusion criteria,60 patients with small cell lung cancer with spleen-yang deficiency undergoing chemotherapy were selected from the second ward of Respiratory and Critical Care Medicine Center of Qingdao Hospital of Traditional Chinese Medicine and randomly divided into treatment group and control group,with 30 cases in each group..The treatment group took Jiawei Lizhong Decoction 3 days in advance on the basis of conventional chemotherapy drugs and western drugs to prevent gastrointestinal side effects for 1 week,while the control group used conventional chemotherapy drugs and western drugs to prevent gastrointestinal side effects,taking 7 days as the treatment cycle,and recorded the gastrointestinal side effects(the frequency and grading of nausea,vomiting and anorexia on the first and seventh days),serum substance P(SP)level The data of serum ghrelin level,TCM syndrome score,laboratory examination,quality of life,etc.were statistically analyzed by SPSS 26.0 statistical software.Results: 1.Gastrointestinal reaction: nausea and vomiting occurred in both groups on day 1 and day 7 of chemotherapy,but the incidence in the treatment group was lower than that in the control group(P<0.05),and the score of nausea and vomiting in the treatment group was also lower than that in the control group(P<0.05).After chemotherapy,loss of appetite appeared in both groups,but the incidence in the treatment group was lower than that in the control group(P<0.05),and the degree of loss of appetite in the treatment group was also lower than that in the control group(P<0.05).2.Serum SP and Ghrelin levels: After chemotherapy,serum SP increased in both groups,but the increase rate in the treatment group was much lower than that in the control group(PSerum Ghrelin was decreased in both groups after chemotherapy,but the decrease in treatment group was less than that in control group(PTCM syndrome score: After chemotherapy,TCM syndrome score of the treatment group decreased significantly compared with that before chemotherapy(P<0.001),while TCM syndrome score of the control group increased after chemotherapy(P<0.05).Compared with the two groups,the treatment group had better effect in improving TCM syndrome(P<0.001).4.Quality of life score: The quality of life score of both groups increased after treatment(P<0.05),and the quality of life was improved.Compared with the two groups,the quality of life improvement of the treatment group was better than that of the control group(P<0.05).5.Safety evaluation: After chemotherapy,the changes of leukocyte(WBC),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in the treatment group were better than those in the control group(P<0.05),and the toxic and side effects of leukopenia and liver function damage in the treatment group were lower than those in the control group(P<0.05).There were no significant differences in platelet(PLT),hemoglobin(HBG)and creatinine(Cr)indexes between the two groups(P>0.05).Conclusion: Taking Jiawei Lizhong Decoction 3 days before the start of chemotherapy cycle can effectively prevent and improve the gastrointestinal side effects of nausea,vomiting and loss of appetite after chemotherapy.It can control the release of SP and maintain the level of Ghrelin.Adding Wei Lizhong Decoction can also improve the clinical symptoms of spleen-yang deficiency in chemotherapy patients,improve patients’ physique and improve the quality of life of chemotherapy patients.In addition,Weilizhong decoction can also reduce the toxic side effects caused by chemotherapy drugs,such as leukopenia and liver function damage. |