Clinical Observation On The Treatment Of COPD In Stable Stage With The Combination Of Geqi Fangchuan Granule And Six Word Formula Breathing Exercise

Objective: In this study,we observed the clinical effect of the treatment of COPD in stable stage(deficiency of lung,kidney,Qi and Yin).In order to evaluate its clinical efficacy and safety,explore its mechanism of action,further enrich the experience of COPD in stable stage,provide scientific basis for pulmonary rehabilitation of COPD patients,and further promote the development of pulmonary rehabilitation in China.Methods:117 patients were randomly divided into western medicine group(A group),Chinese medicine group(B group),respiratory exercise group(C group) and combination group(D group).After three months of treatment,the symptoms,lung function,CAT score,6MWD,mMRC,blood routine,liver and kidney function of the four groups were observed before and after treatment And security.Results:1.Efficacy index: the total effective rate in group A was 57.14%,in group B was 79.31%,in group C was 76.67%,and in group D was 86.67%.There was statistical difference between the two groups(P < 0.05).It shows that the treatment effect of group D is better.2.Total score of TCM syndrome: the total score of TCM syndrome in four groups after treatment was lower than that before treatment,with statistical difference(P < 0.001).The results showed that there was no statistical difference between group B and group C(P > 0.05);group D was lower than group A,group B and group C,with statistical difference(P < 0.05).Group D was the best,group B and group C were the second,the three groups were better than group A.3.Scores of single TCM symptoms: after treatment,scores of all TCM symptoms were reduced compared with those before treatment in the four groups,with statistical differences(P < 0.05).Hyperhidrosis or fatigue;In terms of the scores of three single TCM symptoms,group D was the best,and the comparison between group A,B and C showed no statistical significance in lumbar and knee tenderness.In the score of single symptom of dry cough and less phlegm in traditional Chinese medicine,there was A statistical difference between group B,C and D and group A(P < 0.05),while there was no statistical difference between group B,C and D(P > 0.05).Dizzy tinnitus;In the score of TCM symptoms of night sweats,there was no statistical difference between two groups of four groups A,B,C and D(P > 0.05).4.Lung function index: the results of comparison among the four groups showed that FEV1% perd and FEV1% in group A,B,C and d after treatment were higher than those before treatment,and there was statistical difference(P < 0.05).There was no significant difference between the two groups(P > 0.05).5.mMRC score: the results showed that there was no statistical difference between the dyspnea index of group A after treatment and that before treatment(P > 0.05);after treatment,the dyspnea index of group B,C and D improved compared with that before treatment(P < 0.05).The scores of group A,B and C were all decreased,but there was no statistical significance.6.CAT score: the results showed that the CAT scores of group A,B,C and D were lower than those of group A(P < 0.001).The results of group D and group B were the best,group D was better than group B,group C was the second,the three groups were better than group A.7.6-minute walking test: the results of comparison among the four groups showed that 6MWD after treatment was higher than that before treatment,with statistical difference(P < 0.05).Group D was the best,group C was the second,group B was the second,the three groups were better than group A.Conclusion:1.The combination of Geqi Fangchuan granule and strengthening six word formula breathing exercise can improve the symptoms of cough,wheezing and shortness of breath of COPD patients in the stable period(deficiency of both lung and kidney qi and Yin),relieve the clinical dyspnea,improve the lung function state,delay the declining trend of lung function,improve the patient’s sports endurance,improve the quality of life,and the effect is better than that of single Geqi Fangchuan granule and strengthening six word formula breathing exercise.2.In the aspect of improving clinical symptoms,the effect of traditional Chinese medicine group is better than that of strengthening six word breathing exercise group;in the aspect of improving sports endurance,strengthening six word breathing exercise is better than that of traditional Chinese medicine group.3.There are no toxic and side effects in both Geqi Fangchuan granule and strengthening six word formula breathing exercise,which are worthy of clinical application.